Source:http://linkedlifedata.com/resource/pubmed/id/16636788
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
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| pubmed:dateCreated |
2006-9-4
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| pubmed:abstractText |
Animal studies have shown that not only cortical, but also brainstem and cerebellar areas are involved in the initiation and generation of optokinetic nystagmus (OKN), e.g., cortico-(pretecto)pontine-olivo-cerebellar pathways. The aim of this fMRI study was to identify and differentiate brainstem and cerebellar areas involved in horizontal and vertical OKN (h/vOKN) in humans. In a group of nine healthy volunteers, hOKN and vOKN were statistically compared with a stationary control condition. There were common activated regions for hOKN and vOKN directions located in the transition zone between the posterior thalamus and the mesencephalon bilaterally covering the pretectal nucleus complex, which is known to be a major structure within the afferent branch of the optokinetic system. Furthermore, during hOKN, activation occurred bilaterally in the mediodorsal and dorsolateral ponto-medullary brainstem, which could be best attributed to the reticular formation, especially the paramedian pontine reticular formation (PPRF). For vOKN, additional activated areas in the dorsal mesencephalic brainstem could be best localized to the ocular motor nuclei and the rostral interstitial nucleus of the medial longitudinal fasciculus (riMLF). For both OKN directions, the cerebellar activation was localized in the oculomotor vermis (declive VI, folium and tuber VIIA/B, in part pyramis VIIIA), and the flocculus bilaterally as well as widespread in the cerebellar hemispheres. In conclusion, fMRI allowed first attributions of neuronal substrates in the cerebellum and brainstem to hOKN and vOKN in humans. Consistent with the animal data, the dorsal ponto-medullary routes were involved bilaterally for hOKN, whereas the rostral mesencephalic routes were involved for vOKN.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:status |
MEDLINE
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| pubmed:month |
Sep
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| pubmed:issn |
0014-4819
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
174
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
312-23
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| pubmed:dateRevised |
2009-11-11
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| pubmed:meshHeading |
pubmed-meshheading:16636788-Adult,
pubmed-meshheading:16636788-Brain Mapping,
pubmed-meshheading:16636788-Brain Stem,
pubmed-meshheading:16636788-Cerebellar Cortex,
pubmed-meshheading:16636788-Cerebellum,
pubmed-meshheading:16636788-Female,
pubmed-meshheading:16636788-Humans,
pubmed-meshheading:16636788-Magnetic Resonance Imaging,
pubmed-meshheading:16636788-Male,
pubmed-meshheading:16636788-Neural Pathways,
pubmed-meshheading:16636788-Nystagmus, Optokinetic,
pubmed-meshheading:16636788-Oculomotor Muscles,
pubmed-meshheading:16636788-Orientation,
pubmed-meshheading:16636788-Photic Stimulation,
pubmed-meshheading:16636788-Reticular Formation,
pubmed-meshheading:16636788-Rhombencephalon,
pubmed-meshheading:16636788-Space Perception,
pubmed-meshheading:16636788-Tegmentum Mesencephali,
pubmed-meshheading:16636788-Vestibule, Labyrinth
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| pubmed:year |
2006
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| pubmed:articleTitle |
Brainstem and cerebellar fMRI-activation during horizontal and vertical optokinetic stimulation.
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| pubmed:affiliation |
Department of Neurology, Johannes Gutenberg-University of Mainz, Langenbeckstrasse 1, 55101, Mainz, Germany. bense@neurologie.klinik.uni-mainz.de
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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