Source:http://linkedlifedata.com/resource/pubmed/id/16636456
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
2006-4-25
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| pubmed:abstractText |
We determined the changes in the mutagenic and estrogenic activities of 17beta-estradiol after a nitrite treatment. Nitrite-treated 17beta-estradiol showed mutagenic activities toward Salmonella typhimurium strains TA 100 and TA 98. We confirmed that nitrite-treated 17beta-estradiol generated radicals from the results of an analysis of electron spin resonance. By applying an instrumental analysis, we identified 2-nitro-17beta-estradiol to have been formed in the reaction mixture. 2-Nitro-17beta-estradiol did not exhibit mutagenic activities toward Salmonella typhimurium strains, suggesting that other mutagens might have been formed in the reaction mixture. The clastogenic properties of nitrite-treated 17beta-estradiol and 2-nitro-17beta-estradiol were analyzed by a micronucleus test with male ICR mice. Nitrite-treated 17beta-estradiol and 2-nitro-17beta-estradiol induced a significantly higher frequency of micronucleated reticulocytes in mice. The estrogenic activity of 2-nitro-17beta-estradiol was found to be lower than that of 17beta-estradiol. These data suggest that a daily oral intake of 17beta-estradiol and nitrite might induce the formation of mutagenic compounds in our body.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
0916-8451
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| pubmed:author |
pubmed-author:DeguchiYuyaY,
pubmed-author:KamihiraMiyaM,
pubmed-author:KinaeNaohideN,
pubmed-author:KumazawaShigenoriS,
pubmed-author:MasudaShuichiS,
pubmed-author:OkadaMasakiM,
pubmed-author:SanoAyakoA,
pubmed-author:SugiyamaChitoseC,
pubmed-author:TeraoYoshiyasuY,
pubmed-author:TerashimaYumekoY,
pubmed-author:ToyoizumiTomoyasuT,
pubmed-author:YoshiokaHisashiH
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| pubmed:issnType |
Print
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| pubmed:volume |
70
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
890-6
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:16636456-Animals,
pubmed-meshheading:16636456-Electron Spin Resonance Spectroscopy,
pubmed-meshheading:16636456-Estradiol,
pubmed-meshheading:16636456-Male,
pubmed-meshheading:16636456-Mass Spectrometry,
pubmed-meshheading:16636456-Mice,
pubmed-meshheading:16636456-Mice, Inbred ICR,
pubmed-meshheading:16636456-Molecular Structure,
pubmed-meshheading:16636456-Mutagens,
pubmed-meshheading:16636456-Nitrites,
pubmed-meshheading:16636456-Receptors, Estrogen,
pubmed-meshheading:16636456-Salmonella typhimurium
|
| pubmed:year |
2006
|
| pubmed:articleTitle |
Changes in the mutagenic and estrogenic activities of 17beta-estradiol after treatment with nitrite.
|
| pubmed:affiliation |
Department of Food and Nutritional Sciences, Graduate School of Nutritional and Environmental Sciences, University of Shizuoka, Shizuoka, Japan. masudas@u-shizuoka-ken.ac.jp
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| pubmed:publicationType |
Journal Article
|