| pubmed-article:16634806 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16634806 | lifeskim:mentions | umls-concept:C0024623 | lld:lifeskim |
| pubmed-article:16634806 | lifeskim:mentions | umls-concept:C0042210 | lld:lifeskim |
| pubmed-article:16634806 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:16634806 | lifeskim:mentions | umls-concept:C2349975 | lld:lifeskim |
| pubmed-article:16634806 | lifeskim:mentions | umls-concept:C1705938 | lld:lifeskim |
| pubmed-article:16634806 | lifeskim:mentions | umls-concept:C1527178 | lld:lifeskim |
| pubmed-article:16634806 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:16634806 | pubmed:dateCreated | 2006-4-25 | lld:pubmed |
| pubmed-article:16634806 | pubmed:abstractText | MG7-Ag, gastric cancer-associated antigen, has been shown to be immunogenic and has been used as marker molecule for prognosis. In a previous study, we developed an oral DNA vaccine based on MG7-Ag mimotope. However, we failed to detect cellular immune response using the oral MG7-Ag mimotope DNA vaccine. To induce significant T cell response, we developed a recombinant adenovirus vaccine based on MG7-Ag mimotope and evaluated the efficacy and protective effects of heterologous prime-boost immunization protocol with an oral DNA vaccine previously developed. We found that both vaccines were able to elicit a significant humoral response against MG7-Ag, while the highest serum titre MG7 antibody was detected in mice immunized with the heterologous prime-boost immunization protocol. Enzyme-linked immunospot (ELISPOT) assay demonstrated that the heterologous prime-boost immunization strategy was more efficient in inducing T cell response than the homologous prime-boost strategy. In the tumour challenge assay, 2 of 5 mice immunized with the heterologous prime-boost protocol were tumour free, while none of the mice in homologous prime-boost groups or control groups was tumour free. Those tumour-bearing mice in the heterologous prime-boost regime had smaller tumour masses than their counterparts in the homologous prime-boost groups or control groups. Therefore, our study suggests that vaccines against MG7-Ag induce significant immune response against gastric cancer, and that the heterologous prime-boost protocol using different types of vaccines could achieve better protective effect than the homologous prime-boost protocol. | lld:pubmed |
| pubmed-article:16634806 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16634806 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16634806 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16634806 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16634806 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16634806 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16634806 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16634806 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16634806 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16634806 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16634806 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16634806 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16634806 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16634806 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16634806 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16634806 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16634806 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16634806 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16634806 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16634806 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16634806 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16634806 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16634806 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16634806 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16634806 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16634806 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16634806 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16634806 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16634806 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16634806 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16634806 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16634806 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16634806 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16634806 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16634806 | pubmed:month | May | lld:pubmed |
| pubmed-article:16634806 | pubmed:issn | 0009-9104 | lld:pubmed |
| pubmed-article:16634806 | pubmed:author | pubmed-author:LimRR | lld:pubmed |
| pubmed-article:16634806 | pubmed:author | pubmed-author:LinTT | lld:pubmed |
| pubmed-article:16634806 | pubmed:author | pubmed-author:ChenYY | lld:pubmed |
| pubmed-article:16634806 | pubmed:author | pubmed-author:SunLL | lld:pubmed |
| pubmed-article:16634806 | pubmed:author | pubmed-author:FauMM | lld:pubmed |
| pubmed-article:16634806 | pubmed:author | pubmed-author:GutDD | lld:pubmed |
| pubmed-article:16634806 | pubmed:author | pubmed-author:MensJJ | lld:pubmed |
| pubmed-article:16634806 | pubmed:author | pubmed-author:LiangSS | lld:pubmed |
| pubmed-article:16634806 | pubmed:author | pubmed-author:YuZZ | lld:pubmed |
| pubmed-article:16634806 | pubmed:author | pubmed-author:DingJJ | lld:pubmed |
| pubmed-article:16634806 | pubmed:author | pubmed-author:XiaLL | lld:pubmed |
| pubmed-article:16634806 | pubmed:author | pubmed-author:HamPP | lld:pubmed |
| pubmed-article:16634806 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16634806 | pubmed:volume | 144 | lld:pubmed |
| pubmed-article:16634806 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16634806 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16634806 | pubmed:pagination | 319-25 | lld:pubmed |
| pubmed-article:16634806 | pubmed:dateRevised | 2010-9-16 | lld:pubmed |
| pubmed-article:16634806 | pubmed:meshHeading | pubmed-meshheading:16634806... | lld:pubmed |
| pubmed-article:16634806 | pubmed:meshHeading | pubmed-meshheading:16634806... | lld:pubmed |
| pubmed-article:16634806 | pubmed:meshHeading | pubmed-meshheading:16634806... | lld:pubmed |
| pubmed-article:16634806 | pubmed:meshHeading | pubmed-meshheading:16634806... | lld:pubmed |
| pubmed-article:16634806 | pubmed:meshHeading | pubmed-meshheading:16634806... | lld:pubmed |
| pubmed-article:16634806 | pubmed:meshHeading | pubmed-meshheading:16634806... | lld:pubmed |
| pubmed-article:16634806 | pubmed:meshHeading | pubmed-meshheading:16634806... | lld:pubmed |
| pubmed-article:16634806 | pubmed:meshHeading | pubmed-meshheading:16634806... | lld:pubmed |
| pubmed-article:16634806 | pubmed:meshHeading | pubmed-meshheading:16634806... | lld:pubmed |
| pubmed-article:16634806 | pubmed:meshHeading | pubmed-meshheading:16634806... | lld:pubmed |
| pubmed-article:16634806 | pubmed:meshHeading | pubmed-meshheading:16634806... | lld:pubmed |
| pubmed-article:16634806 | pubmed:meshHeading | pubmed-meshheading:16634806... | lld:pubmed |
| pubmed-article:16634806 | pubmed:meshHeading | pubmed-meshheading:16634806... | lld:pubmed |
| pubmed-article:16634806 | pubmed:meshHeading | pubmed-meshheading:16634806... | lld:pubmed |
| pubmed-article:16634806 | pubmed:meshHeading | pubmed-meshheading:16634806... | lld:pubmed |
| pubmed-article:16634806 | pubmed:meshHeading | pubmed-meshheading:16634806... | lld:pubmed |
| pubmed-article:16634806 | pubmed:meshHeading | pubmed-meshheading:16634806... | lld:pubmed |
| pubmed-article:16634806 | pubmed:meshHeading | pubmed-meshheading:16634806... | lld:pubmed |
| pubmed-article:16634806 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16634806 | pubmed:articleTitle | Enhanced immunogenicity and antitumour effects with heterologous prime-boost regime using vaccines based on MG7-Ag mimotope of gastric cancer. | lld:pubmed |
| pubmed-article:16634806 | pubmed:affiliation | State Key Laboratory of Cancer Biology, Institute of Digestive Diseases, Xijing Hospital, Fourth Military Medical University, 15 Changle West Road, Xi'an 710032, China. | lld:pubmed |
| pubmed-article:16634806 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16634806 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
