| pubmed-article:16634801 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16634801 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:16634801 | lifeskim:mentions | umls-concept:C0031809 | lld:lifeskim |
| pubmed-article:16634801 | lifeskim:mentions | umls-concept:C0206745 | lld:lifeskim |
| pubmed-article:16634801 | lifeskim:mentions | umls-concept:C0085295 | lld:lifeskim |
| pubmed-article:16634801 | lifeskim:mentions | umls-concept:C0021764 | lld:lifeskim |
| pubmed-article:16634801 | lifeskim:mentions | umls-concept:C0678889 | lld:lifeskim |
| pubmed-article:16634801 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:16634801 | pubmed:dateCreated | 2006-4-25 | lld:pubmed |
| pubmed-article:16634801 | pubmed:abstractText | While the impact of Bifidobacterium infantis 35624 and other probiotics on cytokines has been shown in established colitis, the effects of B. infantis consumption in pre-inflammation of interleukin (IL)-10 knock-out (KO) mice and on the wild-type (WT) C57Bl/6 mice have not been well demonstrated. The objective of this study was to examine cytokine responses in mucosal and systemic lymphoid compartments of IL-10 KO mice early in disease and to compare with control WT mice. Mice were fed B. infantis or placebo for 5 weeks and culled prior to the onset of chronic intestinal inflammation (12-14 weeks). The spleen, Peyer's patches and intestinal mucosa were removed and stimulated with various bacterial stimuli. Cytokine levels were measured by enzyme-linked immunosorbent assay. While basal intestinal and systemic cytokine profiles of WT and IL-10 KO mice were similar, transforming growth factor (TGF)-beta was reduced in the spleen of IL-10 KO mice. Following probiotic consumption, interferon (IFN)-gamma was reduced in the Peyer's patch of both WT and IL-10 KO mice. Alterations in IFN-gamma in the Peyer's patches of WT mice (enhancement) versus IL-10 KO (reduction) were observed following in vitro stimulation with salmonella. Differential IL-12p40, CCL2 and CCL5 responses were also observed in IL-10 KO mice and WT mice. The cytokine profile of IL-10 KO mice in early disease was similar to that of WT mice. The most pronounced changes occurred in the Peyer's patch of IL-10 KO mice, suggesting a probiotic mechanism of action independent of IL-10. This study provides a rationale for the use of B. infantis 35624 for the treatment of gastrointestinal inflammation. | lld:pubmed |
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| pubmed-article:16634801 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16634801 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16634801 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16634801 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:16634801 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16634801 | pubmed:month | May | lld:pubmed |
| pubmed-article:16634801 | pubmed:issn | 0009-9104 | lld:pubmed |
| pubmed-article:16634801 | pubmed:author | pubmed-author:MorganJJ | lld:pubmed |
| pubmed-article:16634801 | pubmed:author | pubmed-author:CollinsJ KJK | lld:pubmed |
| pubmed-article:16634801 | pubmed:author | pubmed-author:WatersAA | lld:pubmed |
| pubmed-article:16634801 | pubmed:author | pubmed-author:ShanahanFF | lld:pubmed |
| pubmed-article:16634801 | pubmed:author | pubmed-author:O'MahonyLL | lld:pubmed |
| pubmed-article:16634801 | pubmed:author | pubmed-author:O'RiordanAA | lld:pubmed |
| pubmed-article:16634801 | pubmed:author | pubmed-author:O'CallaghanLL | lld:pubmed |
| pubmed-article:16634801 | pubmed:author | pubmed-author:SheilBB | lld:pubmed |
| pubmed-article:16634801 | pubmed:author | pubmed-author:MacSharryJJ | lld:pubmed |
| pubmed-article:16634801 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16634801 | pubmed:volume | 144 | lld:pubmed |
| pubmed-article:16634801 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16634801 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16634801 | pubmed:pagination | 273-80 | lld:pubmed |
| pubmed-article:16634801 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:16634801 | pubmed:meshHeading | pubmed-meshheading:16634801... | lld:pubmed |
| pubmed-article:16634801 | pubmed:meshHeading | pubmed-meshheading:16634801... | lld:pubmed |
| pubmed-article:16634801 | pubmed:meshHeading | pubmed-meshheading:16634801... | lld:pubmed |
| pubmed-article:16634801 | pubmed:meshHeading | pubmed-meshheading:16634801... | lld:pubmed |
| pubmed-article:16634801 | pubmed:meshHeading | pubmed-meshheading:16634801... | lld:pubmed |
| pubmed-article:16634801 | pubmed:meshHeading | pubmed-meshheading:16634801... | lld:pubmed |
| pubmed-article:16634801 | pubmed:meshHeading | pubmed-meshheading:16634801... | lld:pubmed |
| pubmed-article:16634801 | pubmed:meshHeading | pubmed-meshheading:16634801... | lld:pubmed |
| pubmed-article:16634801 | pubmed:meshHeading | pubmed-meshheading:16634801... | lld:pubmed |
| pubmed-article:16634801 | pubmed:meshHeading | pubmed-meshheading:16634801... | lld:pubmed |
| pubmed-article:16634801 | pubmed:meshHeading | pubmed-meshheading:16634801... | lld:pubmed |
| pubmed-article:16634801 | pubmed:meshHeading | pubmed-meshheading:16634801... | lld:pubmed |
| pubmed-article:16634801 | pubmed:meshHeading | pubmed-meshheading:16634801... | lld:pubmed |
| pubmed-article:16634801 | pubmed:meshHeading | pubmed-meshheading:16634801... | lld:pubmed |
| pubmed-article:16634801 | pubmed:meshHeading | pubmed-meshheading:16634801... | lld:pubmed |
| pubmed-article:16634801 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16634801 | pubmed:articleTitle | Role of interleukin (IL-10) in probiotic-mediated immune modulation: an assessment in wild-type and IL-10 knock-out mice. | lld:pubmed |
| pubmed-article:16634801 | pubmed:affiliation | Department of Medicine and Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland. | lld:pubmed |
| pubmed-article:16634801 | pubmed:publicationType | Journal Article | lld:pubmed |
