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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2006-4-25
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pubmed:abstractText |
While the impact of Bifidobacterium infantis 35624 and other probiotics on cytokines has been shown in established colitis, the effects of B. infantis consumption in pre-inflammation of interleukin (IL)-10 knock-out (KO) mice and on the wild-type (WT) C57Bl/6 mice have not been well demonstrated. The objective of this study was to examine cytokine responses in mucosal and systemic lymphoid compartments of IL-10 KO mice early in disease and to compare with control WT mice. Mice were fed B. infantis or placebo for 5 weeks and culled prior to the onset of chronic intestinal inflammation (12-14 weeks). The spleen, Peyer's patches and intestinal mucosa were removed and stimulated with various bacterial stimuli. Cytokine levels were measured by enzyme-linked immunosorbent assay. While basal intestinal and systemic cytokine profiles of WT and IL-10 KO mice were similar, transforming growth factor (TGF)-beta was reduced in the spleen of IL-10 KO mice. Following probiotic consumption, interferon (IFN)-gamma was reduced in the Peyer's patch of both WT and IL-10 KO mice. Alterations in IFN-gamma in the Peyer's patches of WT mice (enhancement) versus IL-10 KO (reduction) were observed following in vitro stimulation with salmonella. Differential IL-12p40, CCL2 and CCL5 responses were also observed in IL-10 KO mice and WT mice. The cytokine profile of IL-10 KO mice in early disease was similar to that of WT mice. The most pronounced changes occurred in the Peyer's patch of IL-10 KO mice, suggesting a probiotic mechanism of action independent of IL-10. This study provides a rationale for the use of B. infantis 35624 for the treatment of gastrointestinal inflammation.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0009-9104
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
144
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
273-80
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:16634801-Animals,
pubmed-meshheading:16634801-Bifidobacterium,
pubmed-meshheading:16634801-Colitis,
pubmed-meshheading:16634801-Cytokines,
pubmed-meshheading:16634801-Female,
pubmed-meshheading:16634801-Interferon-gamma,
pubmed-meshheading:16634801-Interleukin-10,
pubmed-meshheading:16634801-Intestinal Mucosa,
pubmed-meshheading:16634801-Mice,
pubmed-meshheading:16634801-Mice, Inbred BALB C,
pubmed-meshheading:16634801-Mice, Knockout,
pubmed-meshheading:16634801-Peyer's Patches,
pubmed-meshheading:16634801-Probiotics,
pubmed-meshheading:16634801-Spleen,
pubmed-meshheading:16634801-Transforming Growth Factor beta
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pubmed:year |
2006
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pubmed:articleTitle |
Role of interleukin (IL-10) in probiotic-mediated immune modulation: an assessment in wild-type and IL-10 knock-out mice.
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pubmed:affiliation |
Department of Medicine and Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland.
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pubmed:publicationType |
Journal Article
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