Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2006-4-25
pubmed:abstractText
We examined whether epithelial damage is associated with mobilization of neutrophils or eosinophils in the airway lumen during acute exacerbations of paediatric asthma. Aspirated sputum samples were harvested from 65 paediatric patients (mean age 3.4 +/- 0.4 years) during acute exacerbations of asthma. Patients with signs of infection were excluded. The presence of conglomerates of epithelial cells (i.e. "Creola bodies") in the aspirated sputum was utilized as a marker of epithelial damage. Among the paediatric asthma patients, 60% displayed Creola bodies (CrB+: n = 39) in their sputum samples whereas the remaining patients did not (CrB-: n = 26). CrB+ patients displayed more than a 20-fold increase in the concentration of the neutrophil-mobilizing cytokine interleukin (IL)-8 (pg/ml) and of the neutrophil product neutrophil elastase (NE, g/l), respectively, compared with CrB- patients (IL-8: 7468.2 +/- 1953.6 versus 347.9 +/- 72.6, P < 0.01; NE: 2072.4 +/- 419.0 versus 438.5 +/- 125.7, P < 0.01). Even though not statistically significant, a corresponding trend was observed for the relative number of sputum neutrophils. In contrast, the concentration of the eosinophil-mobilizing cytokine IL-5 and the esoinophil product ECP tended to be lower in CrB+ than in CrB- patients (P > 0.05). In conclusion, as indicated by the analysis of aspirated sputum, epithelial damage is associated with a locally enhanced chemotactic signal for and activity of neutrophils, but not eosinophils, during acute exacerbations of paediatric asthma. It remains to be determined whether these indirect signs of neutrophil mobilization in the airway lumen mirror an increased number of neutrophils in the surrounding airway tissue.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/16634793-10202358, http://linkedlifedata.com/resource/pubmed/commentcorrection/16634793-10228122, http://linkedlifedata.com/resource/pubmed/commentcorrection/16634793-10712320, http://linkedlifedata.com/resource/pubmed/commentcorrection/16634793-12169171, http://linkedlifedata.com/resource/pubmed/commentcorrection/16634793-12226015, http://linkedlifedata.com/resource/pubmed/commentcorrection/16634793-14478653, http://linkedlifedata.com/resource/pubmed/commentcorrection/16634793-15059193, http://linkedlifedata.com/resource/pubmed/commentcorrection/16634793-2096802, http://linkedlifedata.com/resource/pubmed/commentcorrection/16634793-2383179, http://linkedlifedata.com/resource/pubmed/commentcorrection/16634793-2447813, http://linkedlifedata.com/resource/pubmed/commentcorrection/16634793-2690708, http://linkedlifedata.com/resource/pubmed/commentcorrection/16634793-2923380, http://linkedlifedata.com/resource/pubmed/commentcorrection/16634793-3846439, http://linkedlifedata.com/resource/pubmed/commentcorrection/16634793-7697224, http://linkedlifedata.com/resource/pubmed/commentcorrection/16634793-8814050, http://linkedlifedata.com/resource/pubmed/commentcorrection/16634793-9476849, http://linkedlifedata.com/resource/pubmed/commentcorrection/16634793-9476871, http://linkedlifedata.com/resource/pubmed/commentcorrection/16634793-9608008
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0009-9104
pubmed:author
pubmed:issnType
Print
pubmed:volume
144
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
212-6
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed-meshheading:16634793-Acute Disease, pubmed-meshheading:16634793-Asthma, pubmed-meshheading:16634793-Bradykinin, pubmed-meshheading:16634793-Child, Preschool, pubmed-meshheading:16634793-Eosinophil Cationic Protein, pubmed-meshheading:16634793-Eosinophils, pubmed-meshheading:16634793-Epithelial Cells, pubmed-meshheading:16634793-Family Health, pubmed-meshheading:16634793-Female, pubmed-meshheading:16634793-Humans, pubmed-meshheading:16634793-Immunoglobulin E, pubmed-meshheading:16634793-Infant, pubmed-meshheading:16634793-Interleukin-5, pubmed-meshheading:16634793-Interleukin-8, pubmed-meshheading:16634793-Leukocyte Count, pubmed-meshheading:16634793-Leukocyte Elastase, pubmed-meshheading:16634793-Male, pubmed-meshheading:16634793-Neutrophils, pubmed-meshheading:16634793-Sputum, pubmed-meshheading:16634793-Tumor Necrosis Factor-alpha
pubmed:year
2006
pubmed:articleTitle
Association of epithelial damage and signs of neutrophil mobilization in the airways during acute exacerbations of paediatric asthma.
pubmed:affiliation
Department of Paediatrics, Dokkyo University School of Medicine, 880 Kitakobayashi, Mibu, Tochigi 321-0293, Japan. Shigemi@dokkyomed.ac.jp
pubmed:publicationType
Journal Article