Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2006-6-12
pubmed:abstractText
The role of the anti-inflammatory protein annexin-A1 (Anx-A1) in the phagocytic process has been investigated using a murine bone marrow culture-derived macrophage model from Anx-A1(+/+) and Anx-A1(-/-) mice. Macrophages prepared from Anx-A1(-/-) mice exhibited a reduced ingestion of zymosan, Neisseria meningitidis or sheep red blood cells, when compared to Anx-A1(+/+) cells and in the case of zymosan this effect was also mirrored by a reduced clearance in vivo when particles were injected into the peritoneal cavity of Anx-A1(-/-) mice. The ablation of the Anx-A1 gene did not cause any apparent cytoskeletal defects associated with particle ingestion but the cell surface expression of the key adhesion molecule CD11b was depressed in the Anx-A1(-/-) cells providing a possible explanation for the attenuated phagocytic potential of these cells. The production of the cytokines TNFalpha and IL-6 was increased in Anx-A1(-/-) macrophages following phagocytosis of all types of particle.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/16633358-10377187, http://linkedlifedata.com/resource/pubmed/commentcorrection/16633358-10577518, http://linkedlifedata.com/resource/pubmed/commentcorrection/16633358-10679106, http://linkedlifedata.com/resource/pubmed/commentcorrection/16633358-10685363, http://linkedlifedata.com/resource/pubmed/commentcorrection/16633358-10839971, http://linkedlifedata.com/resource/pubmed/commentcorrection/16633358-11395373, http://linkedlifedata.com/resource/pubmed/commentcorrection/16633358-11482905, http://linkedlifedata.com/resource/pubmed/commentcorrection/16633358-11917092, http://linkedlifedata.com/resource/pubmed/commentcorrection/16633358-12368061, http://linkedlifedata.com/resource/pubmed/commentcorrection/16633358-12475898, http://linkedlifedata.com/resource/pubmed/commentcorrection/16633358-12553880, http://linkedlifedata.com/resource/pubmed/commentcorrection/16633358-12560218, http://linkedlifedata.com/resource/pubmed/commentcorrection/16633358-12689596, http://linkedlifedata.com/resource/pubmed/commentcorrection/16633358-12719478, http://linkedlifedata.com/resource/pubmed/commentcorrection/16633358-15022342, http://linkedlifedata.com/resource/pubmed/commentcorrection/16633358-15064349, http://linkedlifedata.com/resource/pubmed/commentcorrection/16633358-15187149, http://linkedlifedata.com/resource/pubmed/commentcorrection/16633358-15238251, http://linkedlifedata.com/resource/pubmed/commentcorrection/16633358-15525555, http://linkedlifedata.com/resource/pubmed/commentcorrection/16633358-15749912, http://linkedlifedata.com/resource/pubmed/commentcorrection/16633358-15778399, http://linkedlifedata.com/resource/pubmed/commentcorrection/16633358-15954894, http://linkedlifedata.com/resource/pubmed/commentcorrection/16633358-16278303, http://linkedlifedata.com/resource/pubmed/commentcorrection/16633358-1826705, http://linkedlifedata.com/resource/pubmed/commentcorrection/16633358-1919019, http://linkedlifedata.com/resource/pubmed/commentcorrection/16633358-2542378, http://linkedlifedata.com/resource/pubmed/commentcorrection/16633358-2971629, http://linkedlifedata.com/resource/pubmed/commentcorrection/16633358-3132914, http://linkedlifedata.com/resource/pubmed/commentcorrection/16633358-687875, http://linkedlifedata.com/resource/pubmed/commentcorrection/16633358-7531748, http://linkedlifedata.com/resource/pubmed/commentcorrection/16633358-7536934, http://linkedlifedata.com/resource/pubmed/commentcorrection/16633358-7582501, http://linkedlifedata.com/resource/pubmed/commentcorrection/16633358-7604972, http://linkedlifedata.com/resource/pubmed/commentcorrection/16633358-7835168, http://linkedlifedata.com/resource/pubmed/commentcorrection/16633358-8673068, http://linkedlifedata.com/resource/pubmed/commentcorrection/16633358-8730738, http://linkedlifedata.com/resource/pubmed/commentcorrection/16633358-9044049, http://linkedlifedata.com/resource/pubmed/commentcorrection/16633358-9134220, http://linkedlifedata.com/resource/pubmed/commentcorrection/16633358-9146893, http://linkedlifedata.com/resource/pubmed/commentcorrection/16633358-9188810, http://linkedlifedata.com/resource/pubmed/commentcorrection/16633358-9191044, http://linkedlifedata.com/resource/pubmed/commentcorrection/16633358-9236448, http://linkedlifedata.com/resource/pubmed/commentcorrection/16633358-9497492, http://linkedlifedata.com/resource/pubmed/commentcorrection/16633358-9576749, http://linkedlifedata.com/resource/pubmed/commentcorrection/16633358-9600863, http://linkedlifedata.com/resource/pubmed/commentcorrection/16633358-9792213, http://linkedlifedata.com/resource/pubmed/commentcorrection/16633358-9831319
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0007-1188
pubmed:author
pubmed:issnType
Print
pubmed:volume
148
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
469-77
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
Impaired phagocytic mechanism in annexin 1 null macrophages.
pubmed:affiliation
Department of Biochemical Pharmacology, The William Harvey Research Institute, St Bartholomew's and the Royal London School of Medicine, University of London.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't