rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
4
|
pubmed:dateCreated |
2006-6-12
|
pubmed:abstractText |
The role of the anti-inflammatory protein annexin-A1 (Anx-A1) in the phagocytic process has been investigated using a murine bone marrow culture-derived macrophage model from Anx-A1(+/+) and Anx-A1(-/-) mice. Macrophages prepared from Anx-A1(-/-) mice exhibited a reduced ingestion of zymosan, Neisseria meningitidis or sheep red blood cells, when compared to Anx-A1(+/+) cells and in the case of zymosan this effect was also mirrored by a reduced clearance in vivo when particles were injected into the peritoneal cavity of Anx-A1(-/-) mice. The ablation of the Anx-A1 gene did not cause any apparent cytoskeletal defects associated with particle ingestion but the cell surface expression of the key adhesion molecule CD11b was depressed in the Anx-A1(-/-) cells providing a possible explanation for the attenuated phagocytic potential of these cells. The production of the cytokines TNFalpha and IL-6 was increased in Anx-A1(-/-) macrophages following phagocytosis of all types of particle.
|
pubmed:grant |
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/16633358-10377187,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16633358-10577518,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16633358-10679106,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16633358-10685363,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16633358-10839971,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16633358-11395373,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16633358-11482905,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16633358-11917092,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16633358-12368061,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16633358-12475898,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16633358-12553880,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16633358-12560218,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16633358-12689596,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16633358-12719478,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16633358-15022342,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16633358-15064349,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16633358-15187149,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16633358-15238251,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16633358-15525555,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16633358-15749912,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16633358-15778399,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16633358-15954894,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16633358-16278303,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16633358-1826705,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16633358-1919019,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16633358-2542378,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16633358-2971629,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16633358-3132914,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16633358-687875,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16633358-7531748,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16633358-7536934,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16633358-7582501,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16633358-7604972,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16633358-7835168,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16633358-8673068,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16633358-8730738,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16633358-9044049,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16633358-9134220,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16633358-9146893,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16633358-9188810,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16633358-9191044,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16633358-9236448,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16633358-9497492,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16633358-9576749,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16633358-9600863,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16633358-9792213,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16633358-9831319
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Jun
|
pubmed:issn |
0007-1188
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
148
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
469-77
|
pubmed:dateRevised |
2009-11-18
|
pubmed:meshHeading |
pubmed-meshheading:16633358-Animals,
pubmed-meshheading:16633358-Annexin A1,
pubmed-meshheading:16633358-Antigens, CD11b,
pubmed-meshheading:16633358-Flow Cytometry,
pubmed-meshheading:16633358-Interleukin-6,
pubmed-meshheading:16633358-Macrophages,
pubmed-meshheading:16633358-Mice,
pubmed-meshheading:16633358-Phagocytosis,
pubmed-meshheading:16633358-Tumor Necrosis Factor-alpha,
pubmed-meshheading:16633358-Zymosan
|
pubmed:year |
2006
|
pubmed:articleTitle |
Impaired phagocytic mechanism in annexin 1 null macrophages.
|
pubmed:affiliation |
Department of Biochemical Pharmacology, The William Harvey Research Institute, St Bartholomew's and the Royal London School of Medicine, University of London.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|