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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2006-5-22
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pubmed:abstractText |
Abnormal cortical and subcortical dopaminergic activities are among the most consistent neuropathological findings in schizophrenia. The molecular mechanisms remain unspecified. NGFI-B and Nurr1 are two closely related transcription factors involved in dopaminergic cell differentiation, maturation, and apoptosis. NGFI-B knockout mice show attenuated behavioral response to dopamine receptor agonists, whereas Nurr1 knockout disrupts midbrain dopaminergic neuron development. To further understand the role of Nurr1 and NGFI-B in schizophrenia and bipolar disorders, we measured Nurr1 and NGFI-B mRNA in the prefrontal cortex Brodmann's areas 9 (BA 9) and BA 46 by in situ hybridization, and the protein levels in BA 9 by Western blotting, of patients with schizophrenia, major depression, and bipolar disorders, and non-psychiatric control subjects (n=15 per group). NGFI-B mRNA (P<0.05) and protein (P<0.01) were significantly lower in patients with schizophrenia (BA 9), and NGFI-B mRNA was lower in bipolar disorder (BA 9 and BA 46) than in the controls. In the deep cortical layers of BA 46, Nurr1 mRNA was significantly (P<0.05) lower in patients with bipolar disorder and schizophrenia than in the controls. Nurr1 protein in BA 9 was significantly lower in major depression (P<0.05) and lower at a trend level in schizophrenia (P=0.056) than in the controls. These data show a deficient prefrontal NGFI-B and Nurr1 expression in schizophrenia and bipolar disorder. Further study may elucidate if and how these deficiencies could be associated with abnormal dopaminergic functions seen in both illnesses.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Complementary,
http://linkedlifedata.com/resource/pubmed/chemical/DNA Primers,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/NR4A1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/NR4A2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Nr4a1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Nr4a2 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Receptor Subfamily 4...,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Receptor Subfamily 4...,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cytoplasmic and Nuclear,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Steroid,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0920-9964
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
84
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
36-56
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pubmed:dateRevised |
2010-9-2
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pubmed:meshHeading |
pubmed-meshheading:16631355-Adult,
pubmed-meshheading:16631355-Bipolar Disorder,
pubmed-meshheading:16631355-Blotting, Western,
pubmed-meshheading:16631355-DNA, Complementary,
pubmed-meshheading:16631355-DNA Primers,
pubmed-meshheading:16631355-DNA-Binding Proteins,
pubmed-meshheading:16631355-Female,
pubmed-meshheading:16631355-Humans,
pubmed-meshheading:16631355-Immunoblotting,
pubmed-meshheading:16631355-In Situ Hybridization,
pubmed-meshheading:16631355-Male,
pubmed-meshheading:16631355-Middle Aged,
pubmed-meshheading:16631355-Nuclear Receptor Subfamily 4, Group A, Member 1,
pubmed-meshheading:16631355-Nuclear Receptor Subfamily 4, Group A, Member 2,
pubmed-meshheading:16631355-Polymerase Chain Reaction,
pubmed-meshheading:16631355-Prefrontal Cortex,
pubmed-meshheading:16631355-RNA, Messenger,
pubmed-meshheading:16631355-Receptors, Cytoplasmic and Nuclear,
pubmed-meshheading:16631355-Receptors, Steroid,
pubmed-meshheading:16631355-Schizophrenia,
pubmed-meshheading:16631355-Transcription Factors
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pubmed:year |
2006
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pubmed:articleTitle |
Reduction of dopamine-related transcription factors Nurr1 and NGFI-B in the prefrontal cortex in schizophrenia and bipolar disorders.
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pubmed:affiliation |
Department of Psychiatry, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814-4799, USA. gxing@usuhs.mil
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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