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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2006-4-24
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pubmed:abstractText |
IL-17F is a recently discovered cytokine that plays a role in tissue inflammation by inducing release of proinflammatory and neutrophil-mobilizing cytokines. Upregulated IL17F gene expression has been observed at sites of allergen challenge in the airways of patients with asthma, suggesting that IL-17F is involved in the pathophysiology of asthma.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0091-6749
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pubmed:author |
pubmed-author:AdachiMitsuruM,
pubmed-author:FukuiYoshinobuY,
pubmed-author:HizawaNobuyukiN,
pubmed-author:HuangShau-KuSK,
pubmed-author:KawaguchiMioM,
pubmed-author:KokubuFumioF,
pubmed-author:KonnoSatoshiS,
pubmed-author:MaedaYukikoY,
pubmed-author:MatsukuraSatoshiS,
pubmed-author:NishimuraMasaharuM,
pubmed-author:SuzukiShintaroS,
pubmed-author:TakahashiDaisukeD
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pubmed:issnType |
Print
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pubmed:volume |
117
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
795-801
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:16630936-Adolescent,
pubmed-meshheading:16630936-Adult,
pubmed-meshheading:16630936-Aged,
pubmed-meshheading:16630936-Amino Acid Substitution,
pubmed-meshheading:16630936-Asthma,
pubmed-meshheading:16630936-Case-Control Studies,
pubmed-meshheading:16630936-Female,
pubmed-meshheading:16630936-Gene Frequency,
pubmed-meshheading:16630936-Genetic Variation,
pubmed-meshheading:16630936-Haplotypes,
pubmed-meshheading:16630936-Homozygote,
pubmed-meshheading:16630936-Humans,
pubmed-meshheading:16630936-Interleukin-17,
pubmed-meshheading:16630936-Japan,
pubmed-meshheading:16630936-MAP Kinase Signaling System,
pubmed-meshheading:16630936-Male,
pubmed-meshheading:16630936-Middle Aged,
pubmed-meshheading:16630936-Polymorphism, Single Nucleotide,
pubmed-meshheading:16630936-Recombinant Proteins
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pubmed:year |
2006
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pubmed:articleTitle |
IL-17F sequence variant (His161Arg) is associated with protection against asthma and antagonizes wild-type IL-17F activity.
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pubmed:affiliation |
First Department of Internal Medicine, Showa University School of Medicine, Tokyo, Japan.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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