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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2006-4-24
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pubmed:abstractText |
Primary adrenal lymphoma is a rare lymphoma with clinical features consisting of a high incidence of bilateral adrenal involvement, diffuse large B-cell histology and secondary adrenal insufficiency. We report a successful treatment of a patient with primary adrenal lymphoma using a combined modality therapy (CMT). A 62-year-old man was hospitalized with pain of the flank, and a computed tomography (CT) scan of the abdomen revealed very large, bilateral adrenal masses. A needle biopsy of the left adrenal mass revealed diffuse large B-cell lymphoma. After irradiation of both adrenal lymphomas and CHOP therapy accompanied by intrathecal treatment and rituximab, the patient underwent a left adrenalectomy and high-dose chemotherapy with autologous peripheral blood stem cell transplantation. The patient has been disease-free for 2 years after the diagnosis of primary adrenal lymphoma. In contrast to the previous reports of poor response to conventional-dose chemotherapy alone and short-term survival of patients with primary adrenal lymphoma, our patient has demonstrated that radiation therapy combined with chemotherapy and rituximab may be an effective modality as a first-line therapeutic regimen for localized primary adrenal lymphoma.
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pubmed:language |
jpn
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0485-1439
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
47
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
204-9
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:16629485-Adrenal Gland Neoplasms,
pubmed-meshheading:16629485-Adrenalectomy,
pubmed-meshheading:16629485-Antibodies, Monoclonal,
pubmed-meshheading:16629485-Antibodies, Monoclonal, Murine-Derived,
pubmed-meshheading:16629485-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:16629485-Combined Modality Therapy,
pubmed-meshheading:16629485-Cyclophosphamide,
pubmed-meshheading:16629485-Doxorubicin,
pubmed-meshheading:16629485-Drug Administration Schedule,
pubmed-meshheading:16629485-Humans,
pubmed-meshheading:16629485-Lymphoma, B-Cell,
pubmed-meshheading:16629485-Lymphoma, Large B-Cell, Diffuse,
pubmed-meshheading:16629485-Male,
pubmed-meshheading:16629485-Middle Aged,
pubmed-meshheading:16629485-Peripheral Blood Stem Cell Transplantation,
pubmed-meshheading:16629485-Prednisolone,
pubmed-meshheading:16629485-Radiotherapy Dosage,
pubmed-meshheading:16629485-Vincristine
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pubmed:year |
2006
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pubmed:articleTitle |
[Effective combined modality therapy for a patient with primary adrenal lymphoma].
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pubmed:affiliation |
Division of Gastroenterology, Chitose City Hospital.
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pubmed:publicationType |
Journal Article,
English Abstract,
Case Reports
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