|
rdf:type |
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|
lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2006-4-24
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pubmed:abstractText |
Oxidative stress occurs early in the progression of Alzheimer disease, significantly before the development of the pathologic hallmarks, neurofibrillary tangles and senile plaques. In the first stage of development of the disease, amyloid-beta deposition and hyperphosphorylated tau function as compensatory responses and downstream adaptations to ensure that neuronal cells do not succumb to oxidative damage. These findings suggest that Alzheimer disease is associated with a novel balance in oxidant homeostasis.
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pubmed:language |
eng
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pubmed:journal |
|
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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|
pubmed:issn |
0716-9760
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pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:volume |
39
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
7-13
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:16629160-Adaptation, Physiological,
pubmed-meshheading:16629160-Alzheimer Disease,
pubmed-meshheading:16629160-Amyloid beta-Peptides,
pubmed-meshheading:16629160-Disease Progression,
pubmed-meshheading:16629160-Glycogen Synthase Kinase 3,
pubmed-meshheading:16629160-Homeostasis,
pubmed-meshheading:16629160-Humans,
pubmed-meshheading:16629160-Neurons,
pubmed-meshheading:16629160-Oxidative Phosphorylation,
pubmed-meshheading:16629160-Oxidative Stress,
pubmed-meshheading:16629160-Protein-Serine-Threonine Kinases
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pubmed:year |
2006
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|
pubmed:articleTitle |
Compensatory responses induced by oxidative stress in Alzheimer disease.
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|
pubmed:affiliation |
Institute of Pathology, Case Western Reserve University, 2085 Adelbert Road, Cleveland, OH 44100, USA.
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|
pubmed:publicationType |
Journal Article,
Review,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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