Source:http://linkedlifedata.com/resource/pubmed/id/16625233
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
9
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pubmed:dateCreated |
2006-8-23
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pubmed:abstractText |
The aim of the study was to examine an association between the Pro12Ala polymorphism of the peroxisome proliferator-activated receptor (PPAR)-gamma2 gene and blood pressure values assessed by 24-h ambulatory blood pressure monitoring (ABPM) in obese patients with long-lasting type II diabetes. Two hundred and fourteen obese patients (95 men and 119 women) with above 10-year history of type II diabetes were recruited for the study. In all the patients, ABPM was performed and other parameters, including age, body mass index (BMI), waist/hip ratio (WHR), haemoglobin A1c (HbA(1c)), serum lipids and creatinine were also evaluated. The Pro12Ala polymorphism was analysed by polymerase chain reaction-restriction fragment length polymorphism. Two subgroups of patients were compared: (a) Pro/Pro: homozygotic Pro/Pro (n=154) and (b) Ala: Ala allele carriers (Ala/Ala+Ala/Pro) (n=60). The studied groups were not different when age, BMI, WHR, HbA(1c), lipids, creatinine and frequency of hypertension were compared. A similar ratio of patients from both groups were treated with angiotensin-converting enzyme inhibitors, calcium channel blockers, diuretics, beta-blockers and alpha-blockers. A difference was observed in a mean 24-h (Ala: 71.9+/-8.1 vs Pro/Pro: 69.4+/-7.8 mm Hg, P=0.034) and a mean night time (Ala: 67.1+/-7.8 vs Pro/Pro: 64.5+/-8.4 mm Hg, P=0.025) diastolic blood pressure, which was significantly higher in patients with Ala variant. There was also a trend towards a higher mean daytime diastolic blood pressure in this group. It seems that the Pro12Ala variant is associated with an increased mean 24-h diastolic blood pressure in obese diabetic patients. Different reaction for antihypertensive medication depending on a variant of the PPAR-gamma2 gene should also be considered as a possible cause of the presented results.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0950-9240
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
20
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
684-92
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pubmed:meshHeading |
pubmed-meshheading:16625233-Alanine,
pubmed-meshheading:16625233-Alleles,
pubmed-meshheading:16625233-Blood Pressure,
pubmed-meshheading:16625233-Body Mass Index,
pubmed-meshheading:16625233-Diabetes Mellitus, Type 2,
pubmed-meshheading:16625233-Female,
pubmed-meshheading:16625233-Humans,
pubmed-meshheading:16625233-Hypertension,
pubmed-meshheading:16625233-Male,
pubmed-meshheading:16625233-Middle Aged,
pubmed-meshheading:16625233-Obesity,
pubmed-meshheading:16625233-PPAR gamma,
pubmed-meshheading:16625233-Polymorphism, Genetic,
pubmed-meshheading:16625233-Proline,
pubmed-meshheading:16625233-Time Factors
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pubmed:year |
2006
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pubmed:articleTitle |
Association between the Pro12Ala variant of the peroxisome proliferator-activated receptor-gamma2 gene and increased 24-h diastolic blood pressure in obese patients with type II diabetes.
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pubmed:affiliation |
Department of Endocrinology, Hypertension and Metabolic Diseases, Pomeranian Medical University, Szczecin, Poland. stefend@sci.pam.szczecin.pl
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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