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rdf:type |
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lifeskim:mentions |
umls-concept:C0006118,
umls-concept:C0009219,
umls-concept:C0017262,
umls-concept:C0018296,
umls-concept:C0085113,
umls-concept:C0178499,
umls-concept:C0205147,
umls-concept:C0332256,
umls-concept:C1171362,
umls-concept:C1514562,
umls-concept:C1515670,
umls-concept:C1519595,
umls-concept:C1880389,
umls-concept:C1881217,
umls-concept:C1883204,
umls-concept:C1883221
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pubmed:issue |
3
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pubmed:dateCreated |
1992-2-7
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pubmed:databankReference |
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/D01226,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/D10490,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/M64055,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/M64056,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/M64057,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/M64058,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/M64059,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/M64060,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/S67100,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/S74102,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/S74367
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pubmed:abstractText |
Neurofibromatosis type 1 (NF1) is an autosomal dominant neurocutaneous disorder. A part of the gene for NF1 was cloned and its deduced protein has a domain functionally related to mammalian ras GTP-ase-activating protein (GAP). Human tissues examined express two types of NF1 mRNAs: an originally identified species of NF1 mRNA (type I) and another one containing the 63 base insert in the region coding for GAP-related domain (type II). However relative levels of both mRNAs seem to change under certain conditions. Human brain expresses type I mRNA predominantly, while type II is preferentially expressed in most primary brain tumors (13/16 tumors analyzed). We suggest that higher levels of type II mRNA may be related to the genesis of brain tumors.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/DNA Transposable Elements,
http://linkedlifedata.com/resource/pubmed/chemical/GTPase-Activating Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Heme Oxygenase (Decyclizing),
http://linkedlifedata.com/resource/pubmed/chemical/Oligodeoxyribonucleotides,
http://linkedlifedata.com/resource/pubmed/chemical/Oligonucleotides, Antisense,
http://linkedlifedata.com/resource/pubmed/chemical/Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Neoplasm,
http://linkedlifedata.com/resource/pubmed/chemical/ras GTPase-Activating Proteins
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0006-291X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
31
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pubmed:volume |
181
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
955-61
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:1662505-Adult,
pubmed-meshheading:1662505-Aged,
pubmed-meshheading:1662505-Amino Acid Sequence,
pubmed-meshheading:1662505-Base Sequence,
pubmed-meshheading:1662505-Brain Neoplasms,
pubmed-meshheading:1662505-Child,
pubmed-meshheading:1662505-DNA Transposable Elements,
pubmed-meshheading:1662505-Female,
pubmed-meshheading:1662505-GTPase-Activating Proteins,
pubmed-meshheading:1662505-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:1662505-Genes, Neurofibromatosis 1,
pubmed-meshheading:1662505-Heme Oxygenase (Decyclizing),
pubmed-meshheading:1662505-Humans,
pubmed-meshheading:1662505-Male,
pubmed-meshheading:1662505-Middle Aged,
pubmed-meshheading:1662505-Molecular Sequence Data,
pubmed-meshheading:1662505-Oligodeoxyribonucleotides,
pubmed-meshheading:1662505-Oligonucleotides, Antisense,
pubmed-meshheading:1662505-Polymerase Chain Reaction,
pubmed-meshheading:1662505-Proteins,
pubmed-meshheading:1662505-RNA, Messenger,
pubmed-meshheading:1662505-RNA, Neoplasm,
pubmed-meshheading:1662505-Restriction Mapping,
pubmed-meshheading:1662505-Transcription, Genetic,
pubmed-meshheading:1662505-ras GTPase-Activating Proteins
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pubmed:year |
1991
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pubmed:articleTitle |
Brain tumors predominantly express the neurofibromatosis type 1 gene transcripts containing the 63 base insert in the region coding for GTPase activating protein-related domain.
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pubmed:affiliation |
Department of Applied Physiology and Molecular Biology, Tohoku University School of Medicine, Miyagi, Japan.
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pubmed:publicationType |
Journal Article
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