Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2006-7-26
pubmed:abstractText
Genomewide gene expression patterns were investigated in inbred and noninbred Drosophila melanogaster lines under benign and stressful (high temperature) environmental conditions in a highly replicated experiment using Affymetrix gene chips. We found that both heat-shock protein and metabolism genes are strongly affected by temperature stress and that genes involved in metabolism are differentially expressed in inbred compared with noninbred lines, and that this effect is accentuated after heat stress exposure. Furthermore we show that inbreeding and temperature stress cause increased between-line variance in gene expression patterns. We conclude that inbreeding and environmental stress both independently and synergistically affect gene expression patterns. Interactions between inbreeding and the environment are often observed at the phenotypic level and our results reveal some of the genes that are involved at the individual gene level. Our observation of several metabolism genes being differentially expressed in inbred lines and more so after exposure to temperature stress, together with lower fitness in the investigated inbred lines, supports the hypothesis that superiority of heterozygous individuals partly derives from increased metabolic efficiency.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/16624914-10592173, http://linkedlifedata.com/resource/pubmed/commentcorrection/16624914-11483584, http://linkedlifedata.com/resource/pubmed/commentcorrection/16624914-12007414, http://linkedlifedata.com/resource/pubmed/commentcorrection/16624914-12407209, http://linkedlifedata.com/resource/pubmed/commentcorrection/16624914-12454642, http://linkedlifedata.com/resource/pubmed/commentcorrection/16624914-12454649, http://linkedlifedata.com/resource/pubmed/commentcorrection/16624914-12671657, http://linkedlifedata.com/resource/pubmed/commentcorrection/16624914-12925520, http://linkedlifedata.com/resource/pubmed/commentcorrection/16624914-14679396, http://linkedlifedata.com/resource/pubmed/commentcorrection/16624914-14693814, http://linkedlifedata.com/resource/pubmed/commentcorrection/16624914-15136717, http://linkedlifedata.com/resource/pubmed/commentcorrection/16624914-15280238, http://linkedlifedata.com/resource/pubmed/commentcorrection/16624914-15282908, http://linkedlifedata.com/resource/pubmed/commentcorrection/16624914-15372091, http://linkedlifedata.com/resource/pubmed/commentcorrection/16624914-15944359, http://linkedlifedata.com/resource/pubmed/commentcorrection/16624914-16033544, http://linkedlifedata.com/resource/pubmed/commentcorrection/16624914-16033546, http://linkedlifedata.com/resource/pubmed/commentcorrection/16624914-16033550, http://linkedlifedata.com/resource/pubmed/commentcorrection/16624914-16221331, http://linkedlifedata.com/resource/pubmed/commentcorrection/16624914-7297851, http://linkedlifedata.com/resource/pubmed/commentcorrection/16624914-7939661
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0016-6731
pubmed:author
pubmed:issnType
Print
pubmed:volume
173
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1329-36
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
Inbreeding by environmental interactions affect gene expression in Drosophila melanogaster.
pubmed:affiliation
Aarhus Centre for Environmental Stress Research (ACES), Department of Ecology and Genetics, University of Aarhus, Denmark. torsten.kristensen@biology.au.dk
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't