| pubmed-article:16624897 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16624897 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:16624897 | lifeskim:mentions | umls-concept:C0004153 | lld:lifeskim |
| pubmed-article:16624897 | lifeskim:mentions | umls-concept:C1708726 | lld:lifeskim |
| pubmed-article:16624897 | lifeskim:mentions | umls-concept:C0003693 | lld:lifeskim |
| pubmed-article:16624897 | lifeskim:mentions | umls-concept:C0728826 | lld:lifeskim |
| pubmed-article:16624897 | lifeskim:mentions | umls-concept:C0439855 | lld:lifeskim |
| pubmed-article:16624897 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:16624897 | pubmed:dateCreated | 2006-6-22 | lld:pubmed |
| pubmed-article:16624897 | pubmed:abstractText | We previously mapped a locus on chromosome 6 with a large effect (LOD > 6) on aortic lesion size in a (C57BL/6J x CAST/Ei) F(2) cross and identified arachidonate 5-lipoxygenase (5LO) as a candidate gene in this region. Subsequent studies with the 5LO knockout model showed effects on atherosclerosis and aortic aneurysms. We now report detailed genetic analysis of the chromosome 6 locus. We created a panel of overlapping and reciprocal subcongenic lines from the B6.CAST Ldlr(-/-) chromosome 6 congenic strain (CON6.Ldlr(-/-)) and analyzed aortic lesion size in different subcongenic lines. Our results revealed that there are at least two subregions, designated as Ath37 and Ath38 that affect the size of aortic lesions independently of 5LO. We also showed that homozygote 5LO null mice develop smaller atherosclerotic lesions. We conclude that the relation between the mouse chromosome 6 locus and atherosclerosis is complex and is due to at least two genes with large effects within this region. This complexity should be considered when interpreting results of knockout studies. | lld:pubmed |
| pubmed-article:16624897 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16624897 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16624897 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16624897 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16624897 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16624897 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16624897 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16624897 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16624897 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16624897 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16624897 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16624897 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16624897 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16624897 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16624897 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16624897 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16624897 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16624897 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16624897 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16624897 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16624897 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16624897 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16624897 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16624897 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16624897 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16624897 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16624897 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16624897 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16624897 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16624897 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16624897 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16624897 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16624897 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16624897 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16624897 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16624897 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16624897 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16624897 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16624897 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16624897 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16624897 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16624897 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16624897 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16624897 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16624897 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16624897 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16624897 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16624897 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16624897 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16624897 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16624897 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16624897 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16624897 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16624897 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16624897 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16624897 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16624897 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16624897 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16624897 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16624897 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16624897 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16624897 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16624897 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16624897 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16624897 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:16624897 | pubmed:issn | 0016-6731 | lld:pubmed |
| pubmed-article:16624897 | pubmed:author | pubmed-author:LusisAldons... | lld:pubmed |
| pubmed-article:16624897 | pubmed:author | pubmed-author:WangXupingX | lld:pubmed |
| pubmed-article:16624897 | pubmed:author | pubmed-author:MehrabianMarg... | lld:pubmed |
| pubmed-article:16624897 | pubmed:author | pubmed-author:GhazalpourAna... | lld:pubmed |
| pubmed-article:16624897 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16624897 | pubmed:volume | 173 | lld:pubmed |
| pubmed-article:16624897 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16624897 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16624897 | pubmed:pagination | 943-51 | lld:pubmed |
| pubmed-article:16624897 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:16624897 | pubmed:meshHeading | pubmed-meshheading:16624897... | lld:pubmed |
| pubmed-article:16624897 | pubmed:meshHeading | pubmed-meshheading:16624897... | lld:pubmed |
| pubmed-article:16624897 | pubmed:meshHeading | pubmed-meshheading:16624897... | lld:pubmed |
| pubmed-article:16624897 | pubmed:meshHeading | pubmed-meshheading:16624897... | lld:pubmed |
| pubmed-article:16624897 | pubmed:meshHeading | pubmed-meshheading:16624897... | lld:pubmed |
| pubmed-article:16624897 | pubmed:meshHeading | pubmed-meshheading:16624897... | lld:pubmed |
| pubmed-article:16624897 | pubmed:meshHeading | pubmed-meshheading:16624897... | lld:pubmed |
| pubmed-article:16624897 | pubmed:meshHeading | pubmed-meshheading:16624897... | lld:pubmed |
| pubmed-article:16624897 | pubmed:meshHeading | pubmed-meshheading:16624897... | lld:pubmed |
| pubmed-article:16624897 | pubmed:meshHeading | pubmed-meshheading:16624897... | lld:pubmed |
| pubmed-article:16624897 | pubmed:meshHeading | pubmed-meshheading:16624897... | lld:pubmed |
| pubmed-article:16624897 | pubmed:meshHeading | pubmed-meshheading:16624897... | lld:pubmed |
| pubmed-article:16624897 | pubmed:meshHeading | pubmed-meshheading:16624897... | lld:pubmed |
| pubmed-article:16624897 | pubmed:meshHeading | pubmed-meshheading:16624897... | lld:pubmed |
