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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
2006-5-17
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pubmed:abstractText |
Fibroblast growth factor (FGF) receptor 3 has been identified as a key regulator of endochondral bone development and of post-natal bone metabolism through its action on growth plate chondrocytes and osteoblasts, respectively. It has also been shown to promote chondrogenesis and cartilage production by cultured pre-chondrogenic cells in response to FGF18. In the current studies, we show that the absence of signaling through Fgfr3 in the joints of Fgfr3(-/-) mice leads to premature cartilage degeneration and early arthritis. Degenerative changes in cartilage matrix included excessive proteolysis of aggrecan core protein and type II collagen, as measured by neo-epitope immunoreactivity. These changes were accompanied by increased expression of metalloproteinase MMP13, type X collagen, cellular hypertrophy and loss of proteoglycan at the articular surface. Using a novel micro-mechanical indentation protocol, it was shown that articular cartilage in the humeral head of 4-month-old Fgfr3(-/-) mice was less resistant to compressive force and less stiff than that of littermate controls. These results identify Fgfr3 signaling as a potential target for intervention in degenerative disorders of cartilage metabolism.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Agc1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Aggrecans,
http://linkedlifedata.com/resource/pubmed/chemical/Chondroitin Sulfate Proteoglycans,
http://linkedlifedata.com/resource/pubmed/chemical/Collagen Type II,
http://linkedlifedata.com/resource/pubmed/chemical/Collagen Type X,
http://linkedlifedata.com/resource/pubmed/chemical/Collagenases,
http://linkedlifedata.com/resource/pubmed/chemical/Epitopes,
http://linkedlifedata.com/resource/pubmed/chemical/Extracellular Matrix Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Lectins, C-Type,
http://linkedlifedata.com/resource/pubmed/chemical/Matrix Metalloproteinase 13,
http://linkedlifedata.com/resource/pubmed/chemical/Mmp13 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Fibroblast Growth...
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0964-6906
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pubmed:author |
pubmed-author:BinetteJ SJS,
pubmed-author:BuschmannM DMD,
pubmed-author:ChanLL,
pubmed-author:HendersonJ EJE,
pubmed-author:LUCC,
pubmed-author:LaflammeFF,
pubmed-author:MeijersTT,
pubmed-author:MortJ SJS,
pubmed-author:PooleA RAR,
pubmed-author:QuennevilleEE,
pubmed-author:Tran-KhanhNN,
pubmed-author:Valverde-FrancoGG,
pubmed-author:WangHH
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
15
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1783-92
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:16624844-Aggrecans,
pubmed-meshheading:16624844-Animals,
pubmed-meshheading:16624844-Arthritis,
pubmed-meshheading:16624844-Cartilage,
pubmed-meshheading:16624844-Cartilage, Articular,
pubmed-meshheading:16624844-Cartilage Diseases,
pubmed-meshheading:16624844-Chondrocytes,
pubmed-meshheading:16624844-Chondroitin Sulfate Proteoglycans,
pubmed-meshheading:16624844-Collagen Type II,
pubmed-meshheading:16624844-Collagen Type X,
pubmed-meshheading:16624844-Collagenases,
pubmed-meshheading:16624844-Crosses, Genetic,
pubmed-meshheading:16624844-Epitopes,
pubmed-meshheading:16624844-Extracellular Matrix Proteins,
pubmed-meshheading:16624844-Lectins, C-Type,
pubmed-meshheading:16624844-Matrix Metalloproteinase 13,
pubmed-meshheading:16624844-Mice,
pubmed-meshheading:16624844-Mice, Transgenic,
pubmed-meshheading:16624844-Osteoblasts,
pubmed-meshheading:16624844-Receptor, Fibroblast Growth Factor, Type 3,
pubmed-meshheading:16624844-Signal Transduction
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pubmed:year |
2006
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pubmed:articleTitle |
Defects in articular cartilage metabolism and early arthritis in fibroblast growth factor receptor 3 deficient mice.
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pubmed:affiliation |
J.T.N. Wong Laboratories for Mineralized Tissue Research, and Centre for Bone and Periodontal Research, McGill University, 740 Avenue Dr Penfield, Montreal H3A 1A4, Quebec, Canada.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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