| pubmed-article:16624804 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16624804 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:16624804 | lifeskim:mentions | umls-concept:C0118111 | lld:lifeskim |
| pubmed-article:16624804 | lifeskim:mentions | umls-concept:C0444626 | lld:lifeskim |
| pubmed-article:16624804 | lifeskim:mentions | umls-concept:C1167622 | lld:lifeskim |
| pubmed-article:16624804 | lifeskim:mentions | umls-concept:C0439855 | lld:lifeskim |
| pubmed-article:16624804 | lifeskim:mentions | umls-concept:C0037791 | lld:lifeskim |
| pubmed-article:16624804 | lifeskim:mentions | umls-concept:C1880371 | lld:lifeskim |
| pubmed-article:16624804 | lifeskim:mentions | umls-concept:C1520153 | lld:lifeskim |
| pubmed-article:16624804 | pubmed:issue | 25 | lld:pubmed |
| pubmed-article:16624804 | pubmed:dateCreated | 2006-6-19 | lld:pubmed |
| pubmed-article:16624804 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16624804 | pubmed:abstractText | Interleukin enhancer binding factor (ILF) is a human transcription factor and a new member of the winged helix/forkhead family. ILF can bind to purine-rich regulatory motifs such as the human T-cell leukemia virus-long terminal region and the interleukin-2 promoter. Here we report the 2.4 A crystal structure of two DNA binding domains of ILF (FOXK1a) binding to a 16-bp DNA duplex containing a promoter sequence. Electrophoretic mobility shift assay studies demonstrate that two ILF-DNA binding domain molecules cooperatively bind to DNA. In addition to the recognition helix recognizing the core sequences through the major groove, the structure shows that wing 1 interacts with the minor groove of DNA, and the H2-H3 loop region makes ionic bonds to the phosphate group, which permits the recognition of DNA. The structure also reveals that the presence of the C-terminal alpha-helix in place of a typical wing 2 in a member of this family alters the orientation of the C-terminal basic residues (RKRRPR) when binding to DNA outside the core sequence. These results provide a new insight into how the DNA binding specificities of winged helix/forkhead proteins may be regulated by their less conserved regions. | lld:pubmed |
| pubmed-article:16624804 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16624804 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16624804 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16624804 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16624804 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16624804 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16624804 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:16624804 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:16624804 | pubmed:author | pubmed-author:SunYuh-JuYJ | lld:pubmed |
| pubmed-article:16624804 | pubmed:author | pubmed-author:HsiaoChwan-De... | lld:pubmed |
| pubmed-article:16624804 | pubmed:author | pubmed-author:HuangCheng-Ya... | lld:pubmed |
| pubmed-article:16624804 | pubmed:author | pubmed-author:ChuangWoei-Je... | lld:pubmed |
| pubmed-article:16624804 | pubmed:author | pubmed-author:ChangChia-Hao... | lld:pubmed |
| pubmed-article:16624804 | pubmed:author | pubmed-author:TsaiKuang-Lei... | lld:pubmed |
| pubmed-article:16624804 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16624804 | pubmed:day | 23 | lld:pubmed |
| pubmed-article:16624804 | pubmed:volume | 281 | lld:pubmed |
| pubmed-article:16624804 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16624804 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16624804 | pubmed:pagination | 17400-9 | lld:pubmed |
| pubmed-article:16624804 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
| pubmed-article:16624804 | pubmed:meshHeading | pubmed-meshheading:16624804... | lld:pubmed |
| pubmed-article:16624804 | pubmed:meshHeading | pubmed-meshheading:16624804... | lld:pubmed |
| pubmed-article:16624804 | pubmed:meshHeading | pubmed-meshheading:16624804... | lld:pubmed |
| pubmed-article:16624804 | pubmed:meshHeading | pubmed-meshheading:16624804... | lld:pubmed |
| pubmed-article:16624804 | pubmed:meshHeading | pubmed-meshheading:16624804... | lld:pubmed |
| pubmed-article:16624804 | pubmed:meshHeading | pubmed-meshheading:16624804... | lld:pubmed |
| pubmed-article:16624804 | pubmed:meshHeading | pubmed-meshheading:16624804... | lld:pubmed |
| pubmed-article:16624804 | pubmed:meshHeading | pubmed-meshheading:16624804... | lld:pubmed |
| pubmed-article:16624804 | pubmed:meshHeading | pubmed-meshheading:16624804... | lld:pubmed |
| pubmed-article:16624804 | pubmed:meshHeading | pubmed-meshheading:16624804... | lld:pubmed |
| pubmed-article:16624804 | pubmed:meshHeading | pubmed-meshheading:16624804... | lld:pubmed |
| pubmed-article:16624804 | pubmed:meshHeading | pubmed-meshheading:16624804... | lld:pubmed |
| pubmed-article:16624804 | pubmed:meshHeading | pubmed-meshheading:16624804... | lld:pubmed |
| pubmed-article:16624804 | pubmed:meshHeading | pubmed-meshheading:16624804... | lld:pubmed |
| pubmed-article:16624804 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16624804 | pubmed:articleTitle | Crystal structure of the human FOXK1a-DNA complex and its implications on the diverse binding specificity of winged helix/forkhead proteins. | lld:pubmed |
| pubmed-article:16624804 | pubmed:affiliation | Institute of Molecular Biology, Academia Sinica, Taipei 115, Taiwan. | lld:pubmed |
| pubmed-article:16624804 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16624804 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:3607 | entrezgene:pubmed | pubmed-article:16624804 | lld:entrezgene |
| entrez-gene:221937 | entrezgene:pubmed | pubmed-article:16624804 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:16624804 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16624804 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16624804 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16624804 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16624804 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16624804 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16624804 | lld:pubmed |
