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rdf:type |
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lifeskim:mentions |
umls-concept:C0014834,
umls-concept:C0020268,
umls-concept:C0034693,
umls-concept:C0127400,
umls-concept:C0175630,
umls-concept:C0175677,
umls-concept:C0205082,
umls-concept:C0205263,
umls-concept:C0333348,
umls-concept:C1280500,
umls-concept:C1363844,
umls-concept:C1522564
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pubmed:issue |
2
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pubmed:dateCreated |
2006-4-20
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pubmed:abstractText |
Severe sepsis and septic shock remain the most common cause of death in intensive care units. The main causes of death in sepsis are the cardiac dysfunction and hypotension resistant to cateolamines. The prevalence of relative adrenal insufficiency in severe sepsis and septic shock was estimated at about 32%-51%. Several meta-analysis demonstrated that high-dose glucocorticoids decreased survival during sepsis, while stress doses of corticosteroids may benefit these patients. The exact reason for such widely divergent outcome produced by different doses of corticosteroid is still not understood. Therefore, the study was undertaken to observe the effects of different doses of hydrocortisone (HC) on circulating and intramyocardial inflammatory mediators in severe septic rats with myocardial injury induced by Escherichia coli (E. coli).
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pubmed:language |
chi
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0578-1310
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
44
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
131-5
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pubmed:meshHeading |
pubmed-meshheading:16624031-Animals,
pubmed-meshheading:16624031-Anti-Inflammatory Agents,
pubmed-meshheading:16624031-Cardiomyopathies,
pubmed-meshheading:16624031-Disease Models, Animal,
pubmed-meshheading:16624031-Dose-Response Relationship, Drug,
pubmed-meshheading:16624031-Escherichia coli,
pubmed-meshheading:16624031-Hydrocortisone,
pubmed-meshheading:16624031-Interleukin-1beta,
pubmed-meshheading:16624031-Male,
pubmed-meshheading:16624031-Muscle Cells,
pubmed-meshheading:16624031-Nitric Oxide,
pubmed-meshheading:16624031-Nitric Oxide Synthase,
pubmed-meshheading:16624031-Rats,
pubmed-meshheading:16624031-Rats, Wistar,
pubmed-meshheading:16624031-Sepsis,
pubmed-meshheading:16624031-Treatment Outcome,
pubmed-meshheading:16624031-Troponin I,
pubmed-meshheading:16624031-Tumor Necrosis Factor-alpha
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pubmed:year |
2006
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pubmed:articleTitle |
[Effects of hydrocortisone on circulating and intramyocardial inflammatory mediators in severe septic rats with myocardial injury induced by Escherichia coli].
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pubmed:affiliation |
Department of Pediatric Intensive Care Unit, Beijing Children's Hospital, Capital University of Medical Sciences, Beijing 100045, China.
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pubmed:publicationType |
Journal Article,
Comparative Study,
English Abstract
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