Linked Life Data

16621532

Source:http://linkedlifedata.com/resource/pubmed/id/16621532

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pubmed-article:16621532pubmed:dateCreated2006-5-8lld:pubmed
pubmed-article:16621532pubmed:abstractText11C-labeled (+)-trans-2-[[(3R,4S)-4-(4-chlorophenyl)-1-methylpiperidin-3-yl]methylsulfanyl]ethanol ([11C]5) and (+)-trans-2-[[(3R,4S)-4-(4-chlorophenyl)-1-methylpiperidin-3-yl]methylsulfanyl]-1-(piperidin-1-yl)ethanone ([11C]6) were synthesized and evaluated as new imaging agents for the norepinephrine transporter (NET). [11C]5 and [11C]6 display high affinity for the NET in vitro (Ki = 0.94 and 0.68 nM, respectively) and significant selectivity over the dopamine (DAT) and serotonin transporters (SERT). Because of their high affinity and favorable transporter selectivities we speculated that these ligands might serve as useful PET agents for imaging NET in vivo. Contrary to our expectations, both of these ligands provided brain images that were more typical of those shown by agents binding to the DAT.lld:pubmed
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pubmed-article:16621532pubmed:dateRevised2007-11-14lld:pubmed
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pubmed-article:16621532pubmed:year2006lld:pubmed
pubmed-article:16621532pubmed:articleTitleDevelopment of new brain imaging agents based upon nocaine-modafinil hybrid monoamine transporter inhibitors.lld:pubmed
pubmed-article:16621532pubmed:affiliationMolecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Building 10, Room B3 C346, 10 Center Drive, Bethesda, MD 20892-1003, USA.lld:pubmed
pubmed-article:16621532pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:16621532pubmed:publicationTypeResearch Support, N.I.H., Extramurallld:pubmed
pubmed-article:16621532pubmed:publicationTypeResearch Support, N.I.H., Intramurallld:pubmed
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