Linked Life Data

16620916

Source:http://linkedlifedata.com/resource/pubmed/id/16620916

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
2006-5-24
pubmed:abstractText
Among various other mechanisms, genetic differences in the production of reactive oxygen species are thought to underlie genetic variation for longevity. Here we report on possible changes in ROS production related processes in response to selection for divergent virgin lifespan in Drosophila. The selection lines were observed to differ significantly in dopamine levels and melanin pigmentation, which is associated with dopamine levels at eclosion. These findings confirm that variation in dopamine levels is associated with genetic variation for longevity. Dopamine has previously been implied in ROS production and in the occurrence of age-related neurodegenerative diseases. In addition, we propose a possible proximate mechanism by which dopamine levels affect longevity in Drosophila: We tested if increased dopamine levels were associated with a "rate-of-living" syndrome of increased activity and respiration levels, thus aggravating the level of oxidative stress. Findings on locomotor activity and oxygen consumption of short-lived flies were in line with expectations. However, the relation is not straightforward, as flies of the long-lived lines did not show any consistent differences in pigmentation or dopamine levels with respect to the control lines. Moreover, long-lived flies also had increased locomotor activity, but showed no consistent differences in respiration rate. This strongly suggests that the response for increased and decreased lifespan may be obtained by different mechanisms.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0047-6374
pubmed:author
pubmed:issnType
Print
pubmed:volume
127
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
610-7
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
Changes in dopamine levels and locomotor activity in response to selection on virgin lifespan in Drosophila melanogaster.
pubmed:affiliation
Evolutionary Genetics, University of Groningen, NL-9751 NN, Haren, The Netherlands. corneel.vermeulen@biology.au.dk
pubmed:publicationType
Journal Article, Comparative Study