|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
4
|
|
pubmed:dateCreated |
2006-4-19
|
|
pubmed:abstractText |
Deep brain stimulation (DBS) of the ventral [anterior internal] capsule/ventral striatum (VC/VS) is under investigation as an alternative to anterior capsulotomy for severe obsessive-compulsive disorder (OCD). In neuroimaging studies of patients with OCD, dysfunction in the orbitofrontal and anterior cingulate cortex, striatum, and thalamus has been identified; and modulation of activity in this circuit has been observed following successful nonsurgical treatment. The purpose of the current study was to test hypotheses regarding changes in regional cerebral blood flow (rCBF) during acute DBS at the VC/VS target in patients with OCD who were participating in a clinical DBS trial.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
AIM
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Apr
|
|
pubmed:issn |
0022-3085
|
|
pubmed:author |
pubmed-author:AlpertNathaniel MNM,
pubmed-author:DoughertyDarin DDD,
pubmed-author:FischmanAlan JAJ,
pubmed-author:FriehsGerhardG,
pubmed-author:GreenbergBenjamin DBD,
pubmed-author:HaberSuzanne NSN,
pubmed-author:MaloneDonaldD,
pubmed-author:RasmussenSteven ASA,
pubmed-author:RauchScott LSL,
pubmed-author:RezaiAliA,
pubmed-author:RiseMark TMT,
pubmed-author:StypulkowskiPaul HPH
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
104
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
558-65
|
|
pubmed:dateRevised |
2006-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:16619660-Adult,
pubmed-meshheading:16619660-Basal Ganglia,
pubmed-meshheading:16619660-Brain,
pubmed-meshheading:16619660-Brain Mapping,
pubmed-meshheading:16619660-Deep Brain Stimulation,
pubmed-meshheading:16619660-Dominance, Cerebral,
pubmed-meshheading:16619660-Female,
pubmed-meshheading:16619660-Frontal Lobe,
pubmed-meshheading:16619660-Humans,
pubmed-meshheading:16619660-Internal Capsule,
pubmed-meshheading:16619660-Male,
pubmed-meshheading:16619660-Nerve Net,
pubmed-meshheading:16619660-Obsessive-Compulsive Disorder,
pubmed-meshheading:16619660-Pilot Projects,
pubmed-meshheading:16619660-Positron-Emission Tomography,
pubmed-meshheading:16619660-Regional Blood Flow
|
|
pubmed:year |
2006
|
|
pubmed:articleTitle |
A functional neuroimaging investigation of deep brain stimulation in patients with obsessive-compulsive disorder.
|
|
pubmed:affiliation |
Division of Psychiatric Neuroscience Research and Neurotherapeutics, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA. rauch@psych.mgh.harvard.edu
|
|
pubmed:publicationType |
Journal Article,
Multicenter Study,
Research Support, N.I.H., Intramural
|
