16619474

Source:http://linkedlifedata.com/resource/pubmed/id/16619474

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0017262, umls-concept:C0031437, umls-concept:C0044602, umls-concept:C0185117, umls-concept:C0251991, umls-concept:C0285761, umls-concept:C0301625, umls-concept:C0755562, umls-concept:C0812413, umls-concept:C1150481, umls-concept:C1368105, umls-concept:C1451005, umls-concept:C1705325, umls-concept:C1999216, umls-concept:C2347168, umls-concept:C2911684
pubmed:issue	2A
pubmed:dateCreated	2006-4-19
pubmed:abstractText	This study aimed to evaluate the impact of selective abrogation of either the MEK/ERK1/2 (UO126 or PD98059) or the PI3K/AKT (LY294002) signaling cascade on cell proliferation, motility and invasion and production of VEGF (collectively termed pro-metastasis phenotypes) in cultured malignant pleural mesothelioma (MPM) cells.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/8102988
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/2-(4-morpholinyl)-8-phenyl-4H-1-benz..., http://linkedlifedata.com/resource/pubmed/chemical/4-((3-bromophenyl)amino)-6,7-dimetho..., http://linkedlifedata.com/resource/pubmed/chemical/Butadienes, http://linkedlifedata.com/resource/pubmed/chemical/Chromones, http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors, http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-8, http://linkedlifedata.com/resource/pubmed/chemical/MAP Kinase Kinase Kinases, http://linkedlifedata.com/resource/pubmed/chemical/Morpholines, http://linkedlifedata.com/resource/pubmed/chemical/Nitriles, http://linkedlifedata.com/resource/pubmed/chemical/Phosphatidylinositol 3-Kinases, http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-akt, http://linkedlifedata.com/resource/pubmed/chemical/Quinazolines, http://linkedlifedata.com/resource/pubmed/chemical/U 0126, http://linkedlifedata.com/resource/pubmed/chemical/Vascular Endothelial Growth Factor A
pubmed:status	MEDLINE
pubmed:issn	0250-7005
pubmed:author	pubmed-author:AllevaAnnette MAM, pubmed-author:ColeGeorge WGWJr, pubmed-author:NguyenDao MDM, pubmed-author:SchrumpDavid SDS, pubmed-author:SehgalShailen SSS, pubmed-author:YeowWen-ShuzWS, pubmed-author:ZuoJing TJT
pubmed:issnType	Print
pubmed:volume	26
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	809-21
pubmed:dateRevised	2010-11-18
pubmed:meshHeading	pubmed-meshheading:16619474-Butadienes, pubmed-meshheading:16619474-Cell Line, Tumor, pubmed-meshheading:16619474-Cell Movement, pubmed-meshheading:16619474-Chromones, pubmed-meshheading:16619474-Enzyme Activation, pubmed-meshheading:16619474-Enzyme Inhibitors, pubmed-meshheading:16619474-Humans, pubmed-meshheading:16619474-Interleukin-8, pubmed-meshheading:16619474-MAP Kinase Kinase Kinases, pubmed-meshheading:16619474-Mesothelioma, pubmed-meshheading:16619474-Morpholines, pubmed-meshheading:16619474-Neoplasm Metastasis, pubmed-meshheading:16619474-Neovascularization, Pathologic, pubmed-meshheading:16619474-Nitriles, pubmed-meshheading:16619474-Phosphatidylinositol 3-Kinases, pubmed-meshheading:16619474-Pleural Neoplasms, pubmed-meshheading:16619474-Proto-Oncogene Proteins c-akt, pubmed-meshheading:16619474-Quinazolines, pubmed-meshheading:16619474-Vascular Endothelial Growth Factor A
pubmed:articleTitle	Suppression of pro-metastasis phenotypes expression in malignant pleural mesothelioma by the PI3K inhibitor LY294002 or the MEK inhibitor UO126.
pubmed:affiliation	Section of Thoracic Oncology, Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
pubmed:publicationType	Journal Article, Research Support, N.I.H., Intramural