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pubmed-article:16619187pubmed:abstractTextIt is not understood why only a subset of individuals infected with Trypanosoma cruzi develop chronic Chagas cardiomyopathy (CCC). Patients with CCC display high levels of circulating proinflammatory cytokines. Heart-infiltrating lymphocytes from patients with CCC also express proinflammatory cytokines (tumor necrosis factor- alpha and interferon- gamma ) that are detectable in biopsy samples and surgical heart-tissue samples. BAT1, a putative anti-inflammatory gene, presents functional polymorphisms in its promoter region that influence its transcriptional level.lld:pubmed
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pubmed-article:16619187pubmed:dateRevised2011-10-17lld:pubmed
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pubmed-article:16619187pubmed:articleTitleBAT1, a putative anti-inflammatory gene, is associated with chronic Chagas cardiomyopathy.lld:pubmed
pubmed-article:16619187pubmed:affiliationHeart Institute (InCor), University of São Paulo, Brazil. ramasawm@usp.brlld:pubmed
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pubmed-article:16619187pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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