|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
10
|
|
pubmed:dateCreated |
2006-4-18
|
|
pubmed:abstractText |
It is not understood why only a subset of individuals infected with Trypanosoma cruzi develop chronic Chagas cardiomyopathy (CCC). Patients with CCC display high levels of circulating proinflammatory cytokines. Heart-infiltrating lymphocytes from patients with CCC also express proinflammatory cytokines (tumor necrosis factor- alpha and interferon- gamma ) that are detectable in biopsy samples and surgical heart-tissue samples. BAT1, a putative anti-inflammatory gene, presents functional polymorphisms in its promoter region that influence its transcriptional level.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
AIM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
May
|
|
pubmed:issn |
0022-1899
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
15
|
|
pubmed:volume |
193
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1394-9
|
|
pubmed:dateRevised |
2011-10-17
|
|
pubmed:meshHeading |
pubmed-meshheading:16619187-Brazil,
pubmed-meshheading:16619187-Chagas Cardiomyopathy,
pubmed-meshheading:16619187-Chronic Disease,
pubmed-meshheading:16619187-DEAD-box RNA Helicases,
pubmed-meshheading:16619187-DNA,
pubmed-meshheading:16619187-Female,
pubmed-meshheading:16619187-Genetic Predisposition to Disease,
pubmed-meshheading:16619187-Humans,
pubmed-meshheading:16619187-Male,
pubmed-meshheading:16619187-Middle Aged,
pubmed-meshheading:16619187-Polymerase Chain Reaction,
pubmed-meshheading:16619187-Polymorphism, Genetic,
pubmed-meshheading:16619187-Polymorphism, Restriction Fragment Length,
pubmed-meshheading:16619187-Promoter Regions, Genetic,
pubmed-meshheading:16619187-RNA Helicases
|
|
pubmed:year |
2006
|
|
pubmed:articleTitle |
BAT1, a putative anti-inflammatory gene, is associated with chronic Chagas cardiomyopathy.
|
|
pubmed:affiliation |
Heart Institute (InCor), University of São Paulo, Brazil. ramasawm@usp.br
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
