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rdf:type |
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lifeskim:mentions |
umls-concept:C0003737,
umls-concept:C0007137,
umls-concept:C0017337,
umls-concept:C0249219,
umls-concept:C0384826,
umls-concept:C0460004,
umls-concept:C0525037,
umls-concept:C0809183,
umls-concept:C1417407,
umls-concept:C1517945,
umls-concept:C2362057
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pubmed:issue |
4
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pubmed:dateCreated |
2006-4-18
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pubmed:abstractText |
To identify the extent and the smallest region of loss for CDKN2B(INK4b), CDKN2A(ARF,INK4a), and MTAP. Homozygous deletions of human chromosome 9p21 occur frequently in malignant cell lines and are common in squamous cell carcinoma of the head and neck (HNSCC). This complex region encodes the tumor suppressor genes cyclin-dependent kinase 2B (CDKN2B) (p15(INK4b)) and CDKN2A (p14(ARF), p16(INK4a)) and the housekeeping gene methylthioadenosine phosphorylase (MTAP).
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0886-4470
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
132
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
409-15
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:16618910-Carcinoma, Squamous Cell,
pubmed-meshheading:16618910-Cell Line, Tumor,
pubmed-meshheading:16618910-Chromosome Mapping,
pubmed-meshheading:16618910-Chromosomes, Human, Pair 9,
pubmed-meshheading:16618910-Cyclin-Dependent Kinase Inhibitor p15,
pubmed-meshheading:16618910-Cyclin-Dependent Kinase Inhibitor p16,
pubmed-meshheading:16618910-DNA, Neoplasm,
pubmed-meshheading:16618910-Gene Deletion,
pubmed-meshheading:16618910-Gene Silencing,
pubmed-meshheading:16618910-Genes, Tumor Suppressor,
pubmed-meshheading:16618910-Genes, p16,
pubmed-meshheading:16618910-Head and Neck Neoplasms,
pubmed-meshheading:16618910-Humans,
pubmed-meshheading:16618910-Purine-Nucleoside Phosphorylase,
pubmed-meshheading:16618910-Tumor Suppressor Protein p14ARF
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pubmed:year |
2006
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pubmed:articleTitle |
Fine-mapping loss of gene architecture at the CDKN2B (p15INK4b), CDKN2A (p14ARF, p16INK4a), and MTAP genes in head and neck squamous cell carcinoma.
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pubmed:affiliation |
Department of Otolaryngology-Head and Neck Surgery and Research Division, Henry Ford Hospital, Detroit, MI 48202, USA. mworsha1@hfhs.org
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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