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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2006-4-18
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pubmed:abstractText |
Genes that are active during normal development are frequently reactivated during neoplastic transformation. We now report that developmentally expressed TAp63 isoforms are frequently reactivated in human squamous cell carcinomas. To determine the consequences of TAp63 reactivation, we induced TAp63alpha expression during chemically-induced skin carcinogenesis. Deregulated TAp63alpha expression dramatically accelerated tumor development and progression, frequently resulting in epithelial-mesenchymal transitions to spindle cell carcinomas and lung metastases. Consistent with this observation, we detected high levels of Twist and N-cadherin in tumors overexpressing TAp63alpha. Thus, as observed for other developmental pathways, aberrant reactivation of TAp63 predisposes to tumor development and progression.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/CKAP4 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Cadherins,
http://linkedlifedata.com/resource/pubmed/chemical/Cdh2 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Cell Adhesion Molecules,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Isoforms,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators,
http://linkedlifedata.com/resource/pubmed/chemical/Trp63 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Twist Transcription Factor
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0008-5472
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
66
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3981-6
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:16618715-Animals,
pubmed-meshheading:16618715-Cadherins,
pubmed-meshheading:16618715-Carcinoma, Squamous Cell,
pubmed-meshheading:16618715-Cell Adhesion Molecules,
pubmed-meshheading:16618715-Cell Transformation, Neoplastic,
pubmed-meshheading:16618715-Disease Progression,
pubmed-meshheading:16618715-Female,
pubmed-meshheading:16618715-Gene Expression Regulation, Developmental,
pubmed-meshheading:16618715-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:16618715-Genetic Predisposition to Disease,
pubmed-meshheading:16618715-Genomic Instability,
pubmed-meshheading:16618715-Head and Neck Neoplasms,
pubmed-meshheading:16618715-Humans,
pubmed-meshheading:16618715-Male,
pubmed-meshheading:16618715-Membrane Proteins,
pubmed-meshheading:16618715-Mice,
pubmed-meshheading:16618715-Mice, Knockout,
pubmed-meshheading:16618715-Mice, Transgenic,
pubmed-meshheading:16618715-Phosphoproteins,
pubmed-meshheading:16618715-Protein Isoforms,
pubmed-meshheading:16618715-Proto-Oncogenes,
pubmed-meshheading:16618715-Skin Neoplasms,
pubmed-meshheading:16618715-Trans-Activators,
pubmed-meshheading:16618715-Twist Transcription Factor
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pubmed:year |
2006
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pubmed:articleTitle |
Reactivation of developmentally expressed p63 isoforms predisposes to tumor development and progression.
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pubmed:affiliation |
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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