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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2006-4-18
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pubmed:abstractText |
Helicobacter pylori CagA-positive strain is associated with gastric adenocarcinoma. CagA is delivered into gastric epithelial cells, where it undergoes tyrosine phosphorylation at the EPIYA sites by Src family kinases (SFKs). Owing to homologous recombination within the 3'-region of the cagA gene, 4 distinct EPIYA sites, each of which is defined by surrounding sequences, are variably assembled in both number and order among CagA proteins from different clinical H pylori isolates. Tyrosine-phosphorylated CagA specifically binds and deregulates SHP-2 via the Western CagA-specific EPIYA-C or East Asian CagA-specific EPIYA-D site, and C-terminal Src kinase (Csk) via the EPIYA-A or EPIYA-B site. Here we investigated the influence of EPIYA-repeat polymorphism on the CagA activity.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Bacterial,
http://linkedlifedata.com/resource/pubmed/chemical/Bacterial Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/CSK tyrosine-protein kinase,
http://linkedlifedata.com/resource/pubmed/chemical/Intracellular Signaling Peptides...,
http://linkedlifedata.com/resource/pubmed/chemical/PTPN11 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Tyrosine Phosphatase...,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Tyrosine Phosphatases,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Tyrosine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Tyrosine,
http://linkedlifedata.com/resource/pubmed/chemical/cagA protein, Helicobacter pylori,
http://linkedlifedata.com/resource/pubmed/chemical/src-Family Kinases
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0016-5085
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
130
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1181-90
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pubmed:dateRevised |
2011-11-2
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pubmed:meshHeading |
pubmed-meshheading:16618412-Antigens, Bacterial,
pubmed-meshheading:16618412-Bacterial Proteins,
pubmed-meshheading:16618412-Cell Line,
pubmed-meshheading:16618412-Humans,
pubmed-meshheading:16618412-Intracellular Signaling Peptides and Proteins,
pubmed-meshheading:16618412-Phenotype,
pubmed-meshheading:16618412-Phosphorylation,
pubmed-meshheading:16618412-Polymorphism, Genetic,
pubmed-meshheading:16618412-Protein Tyrosine Phosphatase, Non-Receptor Type 11,
pubmed-meshheading:16618412-Protein Tyrosine Phosphatases,
pubmed-meshheading:16618412-Protein-Tyrosine Kinases,
pubmed-meshheading:16618412-Repetitive Sequences, Amino Acid,
pubmed-meshheading:16618412-Tyrosine,
pubmed-meshheading:16618412-src-Family Kinases
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pubmed:year |
2006
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pubmed:articleTitle |
Influence of EPIYA-repeat polymorphism on the phosphorylation-dependent biological activity of Helicobacter pylori CagA.
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pubmed:affiliation |
Division of Molecular Oncology, Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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