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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2006-4-14
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pubmed:abstractText |
Soluble glucan, which was obtained from action of glucosyltransferases (GTFs) of Streptococcus mutans on sucrose, was partially hydrolyzed by acetic acid and examined for human T lymphoblast (MOLT-4) stimulating activity. Addition of the partially hydrolyzed glucan (15-60 microg/ml) stimulated human T cell (39-65%) in a dose dependant manner according to MTT assay. Production of interleukine-2 (IL-2) and interleukine-2 receptor (IL-2R) from T cell was increased by 44.5 and 25%, respectively, by addition of partially hydrolyzed glucan (15 microg/ml). These results indicate that stimulation of human T cells by hydrolyzed glucan is probably caused by its effects on stimulating gene expression of IL-2 and IL-2R of human T cell.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0951-6433
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
26
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1-5
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pubmed:meshHeading |
pubmed-meshheading:16614478-Acetic Acid,
pubmed-meshheading:16614478-Gene Expression,
pubmed-meshheading:16614478-Glucans,
pubmed-meshheading:16614478-Glucosyltransferases,
pubmed-meshheading:16614478-Humans,
pubmed-meshheading:16614478-Hydrolysis,
pubmed-meshheading:16614478-Interleukin-2,
pubmed-meshheading:16614478-Lymphocyte Activation,
pubmed-meshheading:16614478-Receptors, Interleukin-2,
pubmed-meshheading:16614478-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:16614478-Solubility,
pubmed-meshheading:16614478-Streptococcus mutans,
pubmed-meshheading:16614478-Sucrose,
pubmed-meshheading:16614478-T-Lymphocytes
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pubmed:year |
2006
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pubmed:articleTitle |
Effect of partially hydrolyzed soluble glucan produced by glucosyltrasferases of Streptococcus mutans on stimulating human T cell.
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pubmed:affiliation |
Korea Food Research Institute, San 46-1, Bundang-gu, Sungnam-si, Kyunggi-do, 463-746, Korea. choiw@kfri.re.kr
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pubmed:publicationType |
Journal Article
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