Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2006-4-14
pubmed:abstractText
Docetaxel, which undergoes hepatic metabolism via cytochrome P450 3A4, is a promising anticancer agent. Toxicity is serious problem, however, because it is difficult to predict the cytochrome P450 3A4 activity of the drug. Moreover, drug-drug interactions involving cytochrome P450 3A4 enzymes are important. Granisetron, a selective antagonist of the 5-hydroxytryptamine3 receptor, also undergoes hepatic metabolism via cytochrome P450 3A4. In this study, we investigated the influence of granisetron on the pharmacokinetics and pharmacodynamics of docetaxel in Asian patients with lung cancer.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1528-9117
pubmed:author
pubmed:issnType
Print
pubmed:volume
12
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
69-72
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed-meshheading:16613665-Adult, pubmed-meshheading:16613665-Aged, pubmed-meshheading:16613665-Antiemetics, pubmed-meshheading:16613665-Antineoplastic Agents, Phytogenic, pubmed-meshheading:16613665-Area Under Curve, pubmed-meshheading:16613665-Asian Continental Ancestry Group, pubmed-meshheading:16613665-Carcinoma, Non-Small-Cell Lung, pubmed-meshheading:16613665-Cytochrome P-450 CYP3A, pubmed-meshheading:16613665-Cytochrome P-450 Enzyme System, pubmed-meshheading:16613665-Drug Interactions, pubmed-meshheading:16613665-Granisetron, pubmed-meshheading:16613665-Humans, pubmed-meshheading:16613665-Lung Neoplasms, pubmed-meshheading:16613665-Male, pubmed-meshheading:16613665-Metabolic Clearance Rate, pubmed-meshheading:16613665-Middle Aged, pubmed-meshheading:16613665-Serotonin Antagonists, pubmed-meshheading:16613665-Taxoids
pubmed:articleTitle
The influence of granisetron on the pharmacokinetics and pharmacodynamics of docetaxel in Asian lung cancer patients.
pubmed:affiliation
Division of Medical Oncology and Molecular Respirology, Department of Multidisciplinary Internal Medicine, Faculty of Medicine, Tottori University, Yonago, Japan.
pubmed:publicationType
Journal Article