Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
1992-1-28
pubmed:abstractText
Herpes simplex virus (HSV) establishes latent infection in the sensory neuron and possibly in non-neuronal tissue, particularly the cornea. During latency only one region of the HSV genome is transcribed, producing RNAs known as latency associated transcripts (LAT). The gene for LAT overlaps with the HSV gene for the protein ICPO in the downstream regions of both genes. Latency can occur in the absence of LAT. This study reports the detection of ICPO/LAT and thymidine kinase (TK) gene fragments by the polymerase chain reaction in DNA extracted from the corneas and trigeminal ganglia of latently infected rabbits. Both genes were detected in four of four trigeminal ganglia tested and in three of five corneas tested. More importantly, this study reports the first detection of LAT in RNA extracted from 9% of corneas from latently infected rabbits (n = 22) by the polymerase chain reaction. LAT was detected in RNA from 100% of the corresponding trigeminal ganglia (n = 22). Although LAT is not essential for latency, it remains the only known molecular marker for latent HSV infections. Detection of LAT in these rabbit corneas suggests that HSV latency may occur in this non-neuronal tissue and that reactivation from non-neuronal tissue may occur at a low frequency in animals in which HSV latency has been established.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/1661140-1004594, http://linkedlifedata.com/resource/pubmed/commentcorrection/1661140-2038719, http://linkedlifedata.com/resource/pubmed/commentcorrection/1661140-205790, http://linkedlifedata.com/resource/pubmed/commentcorrection/1661140-2152989, http://linkedlifedata.com/resource/pubmed/commentcorrection/1661140-2434993, http://linkedlifedata.com/resource/pubmed/commentcorrection/1661140-2448875, http://linkedlifedata.com/resource/pubmed/commentcorrection/1661140-2451758, http://linkedlifedata.com/resource/pubmed/commentcorrection/1661140-2536115, http://linkedlifedata.com/resource/pubmed/commentcorrection/1661140-2538402, http://linkedlifedata.com/resource/pubmed/commentcorrection/1661140-2541237, http://linkedlifedata.com/resource/pubmed/commentcorrection/1661140-2542019, http://linkedlifedata.com/resource/pubmed/commentcorrection/1661140-2542601, http://linkedlifedata.com/resource/pubmed/commentcorrection/1661140-2550571, http://linkedlifedata.com/resource/pubmed/commentcorrection/1661140-2550678, http://linkedlifedata.com/resource/pubmed/commentcorrection/1661140-2552271, http://linkedlifedata.com/resource/pubmed/commentcorrection/1661140-2554642, http://linkedlifedata.com/resource/pubmed/commentcorrection/1661140-2824816, http://linkedlifedata.com/resource/pubmed/commentcorrection/1661140-2824818, http://linkedlifedata.com/resource/pubmed/commentcorrection/1661140-2825014, http://linkedlifedata.com/resource/pubmed/commentcorrection/1661140-2828265, http://linkedlifedata.com/resource/pubmed/commentcorrection/1661140-2831380, http://linkedlifedata.com/resource/pubmed/commentcorrection/1661140-2839575, http://linkedlifedata.com/resource/pubmed/commentcorrection/1661140-2841498, http://linkedlifedata.com/resource/pubmed/commentcorrection/1661140-2842950, http://linkedlifedata.com/resource/pubmed/commentcorrection/1661140-2846336, http://linkedlifedata.com/resource/pubmed/commentcorrection/1661140-2848928, http://linkedlifedata.com/resource/pubmed/commentcorrection/1661140-2925310, http://linkedlifedata.com/resource/pubmed/commentcorrection/1661140-2986322, http://linkedlifedata.com/resource/pubmed/commentcorrection/1661140-3021394, http://linkedlifedata.com/resource/pubmed/commentcorrection/1661140-3035783, http://linkedlifedata.com/resource/pubmed/commentcorrection/1661140-3037020, http://linkedlifedata.com/resource/pubmed/commentcorrection/1661140-3451698, http://linkedlifedata.com/resource/pubmed/commentcorrection/1661140-3785382, http://linkedlifedata.com/resource/pubmed/commentcorrection/1661140-4328483, http://linkedlifedata.com/resource/pubmed/commentcorrection/1661140-4348966, http://linkedlifedata.com/resource/pubmed/commentcorrection/1661140-518835, http://linkedlifedata.com/resource/pubmed/commentcorrection/1661140-6245170, http://linkedlifedata.com/resource/pubmed/commentcorrection/1661140-6262435, http://linkedlifedata.com/resource/pubmed/commentcorrection/1661140-6288065, http://linkedlifedata.com/resource/pubmed/commentcorrection/1661140-6302212, http://linkedlifedata.com/resource/pubmed/commentcorrection/1661140-6306153
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0007-1161
pubmed:author
pubmed:issnType
Print
pubmed:volume
75
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
644-8
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
Latency-associated transcripts in corneas and ganglia of HSV-1 infected rabbits.
pubmed:affiliation
Department of Ophthalmology, Louisiana State, University Medical Center School of Medicine, New Orleans.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't