Source:http://linkedlifedata.com/resource/pubmed/id/16609918
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
2006-4-12
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pubmed:abstractText |
Expression of caveolin-1 and -3 in mouse smooth muscle cells in vivo was examined by immunohistochemistry. Caveolin-1 was detected in almost all smooth muscles examined, except for the pupillary dilator muscle, whereas caveolin-3 was present only in smooth muscles of some specific tissues. In the eye, the pupillary sphincter muscle was intensely positive for caveolin-3, whereas the ciliary muscle and pupillary dilator muscle were negative. In the gastrointestinal tract, caveolin-3 was detected in the inner circular layer, but not in the outer longitudinal layer. Vascular smooth muscle cells of the resistance-sized artery in the uterus and corpus cavernosum were intensely positive for caveolin-3, whereas those of the aorta were only weakly positive and those of the vena cava were negative. Caveolin-3 was also detected in smooth muscle cells of the urinary bladder, ureter, prostatic vas deferens, and seminal vesicle. The different levels of caveolin-3 expression among various smooth muscle tissues were confirmed by Western blot analysis. Even within the same muscle, the relative expression levels of caveolin-1 and -3 were variable among neighboring cells, suggesting distinct fine regulation of expression of these two caveolins. Moreover, even in the same cell, caveolin-1 and -3 showed different distributions. These results indicate that the two caveolins form distinct caveolae in smooth muscles, and that caveolin-1 and -3 serve different functions. Their differential expression may therefore be related to the functional diversity of smooth muscles.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0302-766X
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
324
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
291-300
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pubmed:meshHeading |
pubmed-meshheading:16609918-Animals,
pubmed-meshheading:16609918-Blotting, Western,
pubmed-meshheading:16609918-Caveolin 1,
pubmed-meshheading:16609918-Caveolin 3,
pubmed-meshheading:16609918-Cell Line,
pubmed-meshheading:16609918-Digestive System,
pubmed-meshheading:16609918-Eye,
pubmed-meshheading:16609918-Female,
pubmed-meshheading:16609918-Genitalia,
pubmed-meshheading:16609918-Male,
pubmed-meshheading:16609918-Mice,
pubmed-meshheading:16609918-Mice, Inbred BALB C,
pubmed-meshheading:16609918-Microscopy, Fluorescence,
pubmed-meshheading:16609918-Muscle, Smooth, Vascular,
pubmed-meshheading:16609918-Myocytes, Smooth Muscle,
pubmed-meshheading:16609918-Tissue Distribution,
pubmed-meshheading:16609918-Urinary Tract
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pubmed:year |
2006
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pubmed:articleTitle |
Differential expression of caveolin-3 in mouse smooth muscle cells in vivo.
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pubmed:affiliation |
Department of Anatomy and Molecular Cell Biology, Nagoya University Graduate School of Medicine, Showa-ku, Nagoya, 466-8550, Japan. hkogo@fujita-hu.ac.jp
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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