Linked Life Data

16606588

Source:http://linkedlifedata.com/resource/pubmed/id/16606588

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2006-4-11
pubmed:abstractText
A C-to-T polymorphism in exon 3 of the low density lipoprotein receptor-related protein 1 (LPR-1) gene has been implicated as a risk factor for Alzheimer's disease (AD). The authors performed a meta-analysis to investigate the association between the C766T polymorphism in the LPR-1 gene and the risk for AD. Nineteen references were retrieved through Medline, Cochran Library and CBM search from 1997 to 2004. Similar search strategies were applied to each of these databases. Studies which were eligible for the meta-analysis should meet the following inclusion criteria: presentation of original data and a cross-sectional design, AD as the outcome of interest, an odds ratio (or enough information to calculate it) reported to quantify the association between the frequencies of genotypes and/or alleles of LPR-1 gene C766T polymorphism and the risk for AD. All analyses were performed with Review Manager 4.2. A total of 3,560 AD patients and 3,476 control subjects were analyzed according to the random effect model because some between-study heterogeneity was found (P<0.01). The combined data statistics revealed that there was no statistical difference (test for overall effect: Z=1.74, P=0.08, OR=1.17, 95% CI: 0.98-1.39; Z=1.31, P=0.19, OR=1.11, 95% CI: 0.95-1.31) in the frequencies of allele and genotype between the AD patients and the controls. The meta-analysis showed that the LPR-1 polymorphism was not a major risk factor for AD, although a small effect of the polymorphism for AD risk could not be excluded.
pubmed:language
chi
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0253-9772
pubmed:author
pubmed:issnType
Print
pubmed:volume
28
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
393-8
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
[Meta-analysis of the association of the LRP C766T polymorphism with the risk of Alzheimer's disease].
pubmed:affiliation
West China Hospital, Sichuan University, Chengdu 610041, China. dengying03@126.com
pubmed:publicationType
Journal Article, English Abstract