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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2006-9-4
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pubmed:abstractText |
Two-dimensional gel electrophoresis (2DE) is a powerful technique to examine post-translational modifications of complexly modulated proteins. Currently, spot detection is a necessary step to assess relations between spots and biological variables. This often proves time consuming and difficult when working with non-perfect gels. We developed an analysis technique to measure correlation between 2DE images and biological variables on a pixel by pixel basis. After image alignment and normalization, the biological parameters and pixel values are replaced by their specific rank. These rank adjusted images and parameters are then put into a standard linear Pearson correlation and further tested for significance and variance.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/16606449-10520026,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16606449-10577857,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16606449-10914555,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16606449-11350486,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16606449-12183832,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16606449-12446423,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16606449-12634796,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16606449-12681969,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16606449-12877381,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16606449-12886250,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16606449-15084693,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16606449-15084694,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16606449-15102353,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16606449-15157174,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16606449-15260991,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16606449-15501966,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16606449-15510160,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16606449-15543535,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16606449-15561678,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16606449-15561679,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16606449-15619621,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16606449-15695426,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16606449-15838523,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/16606449-16029452,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16606449-16131611,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16606449-16178797,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16606449-1651754,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/16606449-188440,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16606449-236308,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16606449-468801,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16606449-7564526,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16606449-7607160,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16606449-7657638,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16606449-8161788,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16606449-8616087,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16606449-9607138,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16606449-9652758
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1471-2105
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
7
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
198
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:16606449-Algorithms,
pubmed-meshheading:16606449-Computer Simulation,
pubmed-meshheading:16606449-Electrophoresis, Gel, Two-Dimensional,
pubmed-meshheading:16606449-Gene Expression Profiling,
pubmed-meshheading:16606449-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:16606449-Humans,
pubmed-meshheading:16606449-Leukemia,
pubmed-meshheading:16606449-Models, Biological,
pubmed-meshheading:16606449-Neoplasm Proteins,
pubmed-meshheading:16606449-Protein Processing, Post-Translational,
pubmed-meshheading:16606449-Statistics as Topic,
pubmed-meshheading:16606449-Tumor Markers, Biological,
pubmed-meshheading:16606449-Tumor Suppressor Protein p53
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pubmed:year |
2006
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pubmed:articleTitle |
Correlation analysis of two-dimensional gel electrophoretic protein patterns and biological variables.
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pubmed:affiliation |
Bioinformatics Group, Norut IT, Research Park Tromsø, Postboks 6434, N9294 Tromsø, NO, Norway. werner.van.belle@itek.norut.no
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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