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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1992-1-14
|
| pubmed:abstractText |
In virtually all Ph1 chromosome-positive CML patients, the breakpoint on chromosome 22 maps in a very restricted area of 5.8 Kb, which has been named "breakpoint cluster region" or "bcr". Several molecular probes of this region are presently available, and this makes the molecular diagnosis of CML a useful approach which can be particularly important in those cases in which cytogenetic analysis does not reveal the presence of a Ph1 chromosome. Here we report the problems and our experience during the molecular analysis of the 478 patients examined so far.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0390-6078
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
76
|
| pubmed:geneSymbol |
ABL,
BCR
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
N
|
| pubmed:pagination |
183-7
|
| pubmed:dateRevised |
2010-3-24
|
| pubmed:meshHeading |
pubmed-meshheading:1660437-Base Sequence,
pubmed-meshheading:1660437-Blotting, Southern,
pubmed-meshheading:1660437-DNA Restriction Enzymes,
pubmed-meshheading:1660437-Fusion Proteins, bcr-abl,
pubmed-meshheading:1660437-Gene Rearrangement,
pubmed-meshheading:1660437-Humans,
pubmed-meshheading:1660437-Leukemia, Myelogenous, Chronic, BCR-ABL Positive,
pubmed-meshheading:1660437-Molecular Sequence Data,
pubmed-meshheading:1660437-Oligonucleotide Probes,
pubmed-meshheading:1660437-Philadelphia Chromosome,
pubmed-meshheading:1660437-Polymerase Chain Reaction
|
| pubmed:articleTitle |
Molecular diagnosis of Philadelphia chromosome-positive chronic myeloid leukemia.
|
| pubmed:affiliation |
Istituto di Ematologia Lorenzo e Ariosto Seràgnoli, Università di Bologna, Italy.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|