| pubmed-article:16600857 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16600857 | lifeskim:mentions | umls-concept:C0024501 | lld:lifeskim |
| pubmed-article:16600857 | lifeskim:mentions | umls-concept:C0072899 | lld:lifeskim |
| pubmed-article:16600857 | lifeskim:mentions | umls-concept:C0678558 | lld:lifeskim |
| pubmed-article:16600857 | lifeskim:mentions | umls-concept:C0678640 | lld:lifeskim |
| pubmed-article:16600857 | lifeskim:mentions | umls-concept:C1706937 | lld:lifeskim |
| pubmed-article:16600857 | lifeskim:mentions | umls-concept:C0721534 | lld:lifeskim |
| pubmed-article:16600857 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:16600857 | pubmed:dateCreated | 2006-4-7 | lld:pubmed |
| pubmed-article:16600857 | pubmed:abstractText | Activity-dependent synaptic delivery of GluR1-, GluR2L-, and GluR4-containing AMPA receptors (-Rs) and removal of GluR2-containing AMPA-Rs mediate synaptic potentiation and depression, respectively. The obvious puzzle is how synapses maintain the capacity for bidirectional plasticity if different AMPA-Rs are utilized for potentiation and depression. Here, we show that synaptic AMPA-R exchange is essential for maintaining the capacity for bidirectional plasticity. The exchange process consists of activity-independent synaptic removal of GluR1-, GluR2L-, or GluR4-containing AMPA-Rs and refilling with GluR2-containing AMPA-Rs at hippocampal and cortical synapses in vitro and in intact brains. In GluR1 and GluR2 knockout mice, initiation or completion of synaptic AMPA-R exchange is compromised, respectively. The complementary AMPA-R removal and refilling events in the exchange process ultimately maintain synaptic strength unchanged, but their long rate time constants ( approximately 15-18 hr) render transmission temporarily depressed in the middle of the exchange. These results suggest that the previously hypothesized "slot" proteins, rather than AMPA-Rs, code and maintain transmission efficacy at central synapses. | lld:pubmed |
| pubmed-article:16600857 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16600857 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16600857 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16600857 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16600857 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16600857 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16600857 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16600857 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16600857 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16600857 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16600857 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16600857 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16600857 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16600857 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:16600857 | pubmed:issn | 0896-6273 | lld:pubmed |
| pubmed-article:16600857 | pubmed:author | pubmed-author:StornettaRuth... | lld:pubmed |
| pubmed-article:16600857 | pubmed:author | pubmed-author:ZhuJ JuliusJJ | lld:pubmed |
| pubmed-article:16600857 | pubmed:author | pubmed-author:McCormackStef... | lld:pubmed |
| pubmed-article:16600857 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16600857 | pubmed:day | 6 | lld:pubmed |
| pubmed-article:16600857 | pubmed:volume | 50 | lld:pubmed |
| pubmed-article:16600857 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16600857 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16600857 | pubmed:pagination | 75-88 | lld:pubmed |
| pubmed-article:16600857 | pubmed:dateRevised | 2011-9-22 | lld:pubmed |
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| pubmed-article:16600857 | pubmed:meshHeading | pubmed-meshheading:16600857... | lld:pubmed |
| pubmed-article:16600857 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16600857 | pubmed:articleTitle | Synaptic AMPA receptor exchange maintains bidirectional plasticity. | lld:pubmed |
| pubmed-article:16600857 | pubmed:affiliation | Department of Pharmacology, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA. | lld:pubmed |
| pubmed-article:16600857 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16600857 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:16600857 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:16600857 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:16600857 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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