Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2006-4-7
pubmed:abstractText
Activity-dependent synaptic delivery of GluR1-, GluR2L-, and GluR4-containing AMPA receptors (-Rs) and removal of GluR2-containing AMPA-Rs mediate synaptic potentiation and depression, respectively. The obvious puzzle is how synapses maintain the capacity for bidirectional plasticity if different AMPA-Rs are utilized for potentiation and depression. Here, we show that synaptic AMPA-R exchange is essential for maintaining the capacity for bidirectional plasticity. The exchange process consists of activity-independent synaptic removal of GluR1-, GluR2L-, or GluR4-containing AMPA-Rs and refilling with GluR2-containing AMPA-Rs at hippocampal and cortical synapses in vitro and in intact brains. In GluR1 and GluR2 knockout mice, initiation or completion of synaptic AMPA-R exchange is compromised, respectively. The complementary AMPA-R removal and refilling events in the exchange process ultimately maintain synaptic strength unchanged, but their long rate time constants ( approximately 15-18 hr) render transmission temporarily depressed in the middle of the exchange. These results suggest that the previously hypothesized "slot" proteins, rather than AMPA-Rs, code and maintain transmission efficacy at central synapses.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0896-6273
pubmed:author
pubmed:issnType
Print
pubmed:day
6
pubmed:volume
50
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
75-88
pubmed:dateRevised
2011-9-22
pubmed:meshHeading
pubmed-meshheading:16600857-Anesthetics, Local, pubmed-meshheading:16600857-Animals, pubmed-meshheading:16600857-Animals, Newborn, pubmed-meshheading:16600857-Brain, pubmed-meshheading:16600857-Electric Stimulation, pubmed-meshheading:16600857-Green Fluorescent Proteins, pubmed-meshheading:16600857-Long-Term Potentiation, pubmed-meshheading:16600857-Long-Term Synaptic Depression, pubmed-meshheading:16600857-Magnesium, pubmed-meshheading:16600857-Mice, pubmed-meshheading:16600857-Mice, Knockout, pubmed-meshheading:16600857-Neuronal Plasticity, pubmed-meshheading:16600857-Neurons, pubmed-meshheading:16600857-Patch-Clamp Techniques, pubmed-meshheading:16600857-Rats, pubmed-meshheading:16600857-Receptors, AMPA, pubmed-meshheading:16600857-Synapses, pubmed-meshheading:16600857-Synaptic Transmission, pubmed-meshheading:16600857-Tetrodotoxin, pubmed-meshheading:16600857-Time Factors, pubmed-meshheading:16600857-Transfection, pubmed-meshheading:16600857-Vibrissae
pubmed:year
2006
pubmed:articleTitle
Synaptic AMPA receptor exchange maintains bidirectional plasticity.
pubmed:affiliation
Department of Pharmacology, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA.
pubmed:publicationType
Journal Article, Comparative Study, In Vitro, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural