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PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
2007-4-3
pubmed:abstractText
Some cytokines have been involved in the pathogenesis of late onset Alzheimer's disease (LOAD). A possible increase in plasma cytokines levels has been reported in LOAD and vascular dementia (VD), but the results of previous studies are conflicting. We evaluated the plasma levels of IL-6, TNF-alpha, IL-1beta, and IL-10 in four groups of older individuals: 60 patients with LOAD, 80 patients with VD, 40 subjects with cerebrovascular disease but without dementia (CDND), and 42 controls (C). By analysis of covariance (adjustment for age, gender, coronary heart disease, diabetes, hypertension, smoking, and alcohol consumption) we found that: *IL-1beta was higher in VD, LOAD, and CDND compared with controls (p<0.005). *TNF-alpha was higher in VD and LOAD compared to C (p<0.05), and in VD compared to LOAD (p<0.03). *IL-6 was higher in VD compared with LOAD (p<0.03). No differences in IL-10 values were found (Kruskal-Wallis, Asymp. Sig. 0.14). By logistic regression analysis, we demonstrated that high levels (defined as above the median) of IL-1beta and TNF-alpha, but not of IL-6, were associated with increased likelihood of having VD and LOAD compared to C, while high IL-6 levels were associated with a increased probability of having VD, compared with LOAD. Our study support the notion of a low-grade systemic inflammation in older patients with LOAD or VD, characterized by an increase in plasma IL-1beta and TNF-alpha levels. The high IL-6 levels found in VD might be not a specific finding, as it might come from several conditions including atherosclerosis and related vascular risk factors, comorbidity, and frailty.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0022-3956
pubmed:author
pubmed:issnType
Print
pubmed:volume
41
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
686-93
pubmed:meshHeading
pubmed-meshheading:16600299-Aged, pubmed-meshheading:16600299-Aged, 80 and over, pubmed-meshheading:16600299-Alzheimer Disease, pubmed-meshheading:16600299-Cerebrovascular Disorders, pubmed-meshheading:16600299-Cytokines, pubmed-meshheading:16600299-Dementia, Vascular, pubmed-meshheading:16600299-Female, pubmed-meshheading:16600299-Humans, pubmed-meshheading:16600299-Inflammation, pubmed-meshheading:16600299-Interleukin-10, pubmed-meshheading:16600299-Interleukin-1beta, pubmed-meshheading:16600299-Interleukin-6, pubmed-meshheading:16600299-Likelihood Functions, pubmed-meshheading:16600299-Logistic Models, pubmed-meshheading:16600299-Male, pubmed-meshheading:16600299-Mental Status Schedule, pubmed-meshheading:16600299-Reference Values, pubmed-meshheading:16600299-Risk Factors, pubmed-meshheading:16600299-Tumor Necrosis Factor-alpha
pubmed:year
2007
pubmed:articleTitle
Plasma cytokines profile in older subjects with late onset Alzheimer's disease or vascular dementia.
pubmed:affiliation
Department of Clinical and Experimental Medicine, Section of Internal Medicine, Gerontology and Geriatrics, University of Ferrara, and Long Term Division, Ca' Foncello Hospital, Treviso, Italy. gzuliani@hotmail.com
pubmed:publicationType
Journal Article