Source:http://linkedlifedata.com/resource/pubmed/id/16598383
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
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pubmed:dateCreated |
2006-4-6
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pubmed:abstractText |
A novel role for IGF-I in MSC chondrogenesis was determined. IGF-I effects were evaluated in the presence or absence of TGF-beta signaling by conditionally inactivating the TGF-beta type II receptor. We found that IGF-I had potent chondroinductive actions on MSCs. IGF-I effects were independent from and additive to TGF-beta.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0884-0431
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
21
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
626-36
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:16598383-Animals,
pubmed-meshheading:16598383-Bone Marrow Cells,
pubmed-meshheading:16598383-Chondrocytes,
pubmed-meshheading:16598383-Chondrogenesis,
pubmed-meshheading:16598383-Humans,
pubmed-meshheading:16598383-Insulin-Like Growth Factor I,
pubmed-meshheading:16598383-Mesenchymal Stem Cells,
pubmed-meshheading:16598383-Mice,
pubmed-meshheading:16598383-Signal Transduction,
pubmed-meshheading:16598383-Transforming Growth Factor beta
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pubmed:year |
2006
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pubmed:articleTitle |
Effect of IGF-I in the chondrogenesis of bone marrow mesenchymal stem cells in the presence or absence of TGF-beta signaling.
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pubmed:affiliation |
Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-2579, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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