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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2006-4-6
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pubmed:abstractText |
Osteocytes are suggested to have a crucial role in the initial resorptive phase of bone turnover after microdamage. To study the role of osteocytes in targeted remodeling, we developed an in vitro model, in which osteocytes can be locally damaged and their interactions with bone marrow cells studied. Our results show that the damaged osteocytes activate the osteoclast precursors by soluble factors and thus can control the initial phase of targeted remodeling.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0884-0431
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
21
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
616-25
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:16598382-Animals,
pubmed-meshheading:16598382-Bone Marrow Cells,
pubmed-meshheading:16598382-Carrier Proteins,
pubmed-meshheading:16598382-Cell Culture Techniques,
pubmed-meshheading:16598382-Cell Differentiation,
pubmed-meshheading:16598382-Cells, Cultured,
pubmed-meshheading:16598382-Gels,
pubmed-meshheading:16598382-Macrophage Colony-Stimulating Factor,
pubmed-meshheading:16598382-Membrane Glycoproteins,
pubmed-meshheading:16598382-Mice,
pubmed-meshheading:16598382-Osteocytes,
pubmed-meshheading:16598382-RANK Ligand,
pubmed-meshheading:16598382-Receptor Activator of Nuclear Factor-kappa B,
pubmed-meshheading:16598382-Stress, Mechanical
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pubmed:year |
2006
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pubmed:articleTitle |
Bone marrow cell differentiation induced by mechanically damaged osteocytes in 3D gel-embedded culture.
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pubmed:affiliation |
Department of Biorobotics, Faculty of Engineering, Kyushu Sangyo University, Fukuoka, Japan. kurata@ip.kyusan-u.ac.jp
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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