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| pubmed-article:1659808 | lifeskim:mentions | umls-concept:C0031686 | lld:lifeskim |
| pubmed-article:1659808 | lifeskim:mentions | umls-concept:C0600499 | lld:lifeskim |
| pubmed-article:1659808 | lifeskim:mentions | umls-concept:C1283195 | lld:lifeskim |
| pubmed-article:1659808 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:1659808 | pubmed:dateCreated | 1992-1-2 | lld:pubmed |
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| pubmed-article:1659808 | pubmed:abstractText | Multiple catalytic subunits of the Ca2+ and calmodulin (CaM)-dependent protein phosphatase (PrP) ("calcineurin" or PrP-2B) are derived from at least two structural genes, type 1 ("calcineurin A alpha") and type 2 ("calcineurin A beta "), each of which can produce alternatively spliced transcripts. To examine the possible linkage of these genes, we analyzed genomic DNA from human/hamster hybrid cell lines using probes of 122 base pairs that were designed to bind selectively to exon 3 of the open reading frame. In this region, the nucleotide sequence of the type 2 murine cDNA that we cloned was greater than 99% identical to the type 2 human cDNA but only 78% identical to the type 1 human cDNA. Hybridization to Southern blots containing DNA from all human chromosomes showed that gene 1 was found on chromosome 4, whereas gene 2 segregated to chromosome 10. These data suggest that expression of the two calcineurin genes is not physically linked. | lld:pubmed |
| pubmed-article:1659808 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1659808 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1659808 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:1659808 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1659808 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:1659808 | pubmed:issn | 0006-291X | lld:pubmed |
| pubmed-article:1659808 | pubmed:author | pubmed-author:KincaidR LRL | lld:pubmed |
| pubmed-article:1659808 | pubmed:author | pubmed-author:HiguchiSS | lld:pubmed |
| pubmed-article:1659808 | pubmed:author | pubmed-author:GodeK GKG | lld:pubmed |
| pubmed-article:1659808 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1659808 | pubmed:day | 27 | lld:pubmed |
| pubmed-article:1659808 | pubmed:volume | 181 | lld:pubmed |
| pubmed-article:1659808 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1659808 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1659808 | pubmed:pagination | 252-8 | lld:pubmed |
| pubmed-article:1659808 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:1659808 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:1659808 | pubmed:articleTitle | Chromosomal mapping of the human genes for the calmodulin-dependent protein phosphatase (calcineurin) catalytic subunit. | lld:pubmed |
| pubmed-article:1659808 | pubmed:affiliation | Section on Immunology, National Institute on Alcohol Abuse and Alcoholism, Rockville, MD 20852. | lld:pubmed |
| pubmed-article:1659808 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1659808 | pubmed:publicationType | Comparative Study | lld:pubmed |
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