| pubmed-article:16597102 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16597102 | lifeskim:mentions | umls-concept:C0018026 | lld:lifeskim |
| pubmed-article:16597102 | lifeskim:mentions | umls-concept:C0443286 | lld:lifeskim |
| pubmed-article:16597102 | lifeskim:mentions | umls-concept:C0220781 | lld:lifeskim |
| pubmed-article:16597102 | lifeskim:mentions | umls-concept:C1883254 | lld:lifeskim |
| pubmed-article:16597102 | lifeskim:mentions | umls-concept:C1948027 | lld:lifeskim |
| pubmed-article:16597102 | lifeskim:mentions | umls-concept:C0072166 | lld:lifeskim |
| pubmed-article:16597102 | lifeskim:mentions | umls-concept:C0215830 | lld:lifeskim |
| pubmed-article:16597102 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:16597102 | pubmed:dateCreated | 2006-4-6 | lld:pubmed |
| pubmed-article:16597102 | pubmed:abstractText | [reaction: see text] Propargylamines have been synthesized by a gold(III) salen complex-catalyzed three-component coupling reaction of aldehydes, amines, and alkynes in water in excellent yields at 40 degrees C. With chiral prolinol derivatives as the amine component, excellent diastereoselectivities (up to 99:1) have been attained. This coupling reaction has been applied to the synthesis of propargylamine-modified artemisinin derivatives with the delicate endoperoxide moieties remaining intact. Cytotoxicities with IC(50) values up to 1.1 microM against a human hepatocellular carcinoma cell line (HepG2) were exhibited by these artemisinin derivatives. | lld:pubmed |
| pubmed-article:16597102 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16597102 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16597102 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16597102 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16597102 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16597102 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16597102 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16597102 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16597102 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16597102 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16597102 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16597102 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16597102 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:16597102 | pubmed:issn | 1523-7060 | lld:pubmed |
| pubmed-article:16597102 | pubmed:author | pubmed-author:CheChi-MingCM | lld:pubmed |
| pubmed-article:16597102 | pubmed:author | pubmed-author:WongMan-KinMK | lld:pubmed |
| pubmed-article:16597102 | pubmed:author | pubmed-author:LiuYungenY | lld:pubmed |
| pubmed-article:16597102 | pubmed:author | pubmed-author:LoVanessa... | lld:pubmed |
| pubmed-article:16597102 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16597102 | pubmed:day | 13 | lld:pubmed |
| pubmed-article:16597102 | pubmed:volume | 8 | lld:pubmed |
| pubmed-article:16597102 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16597102 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16597102 | pubmed:pagination | 1529-32 | lld:pubmed |
| pubmed-article:16597102 | pubmed:meshHeading | pubmed-meshheading:16597102... | lld:pubmed |
| pubmed-article:16597102 | pubmed:meshHeading | pubmed-meshheading:16597102... | lld:pubmed |
| pubmed-article:16597102 | pubmed:meshHeading | pubmed-meshheading:16597102... | lld:pubmed |
| pubmed-article:16597102 | pubmed:meshHeading | pubmed-meshheading:16597102... | lld:pubmed |
| pubmed-article:16597102 | pubmed:meshHeading | pubmed-meshheading:16597102... | lld:pubmed |
| pubmed-article:16597102 | pubmed:meshHeading | pubmed-meshheading:16597102... | lld:pubmed |
| pubmed-article:16597102 | pubmed:meshHeading | pubmed-meshheading:16597102... | lld:pubmed |
| pubmed-article:16597102 | pubmed:meshHeading | pubmed-meshheading:16597102... | lld:pubmed |
| pubmed-article:16597102 | pubmed:meshHeading | pubmed-meshheading:16597102... | lld:pubmed |
| pubmed-article:16597102 | pubmed:meshHeading | pubmed-meshheading:16597102... | lld:pubmed |
| pubmed-article:16597102 | pubmed:meshHeading | pubmed-meshheading:16597102... | lld:pubmed |
| pubmed-article:16597102 | pubmed:meshHeading | pubmed-meshheading:16597102... | lld:pubmed |
| pubmed-article:16597102 | pubmed:meshHeading | pubmed-meshheading:16597102... | lld:pubmed |
| pubmed-article:16597102 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16597102 | pubmed:articleTitle | Gold(III) Salen complex-catalyzed synthesis of propargylamines via a three-component coupling reaction. | lld:pubmed |
| pubmed-article:16597102 | pubmed:affiliation | Department of Chemistry and Open Laboratory of Chemical Biology of the Institute of Molecular Technology for Drug Discovery and Synthesis, The University of Hong Kong, Pokfulam Road, Hong Kong, China. | lld:pubmed |
| pubmed-article:16597102 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16597102 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16597102 | lld:pubmed |
