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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2006-4-6
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pubmed:abstractText |
[reaction: see text] Propargylamines have been synthesized by a gold(III) salen complex-catalyzed three-component coupling reaction of aldehydes, amines, and alkynes in water in excellent yields at 40 degrees C. With chiral prolinol derivatives as the amine component, excellent diastereoselectivities (up to 99:1) have been attained. This coupling reaction has been applied to the synthesis of propargylamine-modified artemisinin derivatives with the delicate endoperoxide moieties remaining intact. Cytotoxicities with IC(50) values up to 1.1 microM against a human hepatocellular carcinoma cell line (HepG2) were exhibited by these artemisinin derivatives.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1523-7060
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
13
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pubmed:volume |
8
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1529-32
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pubmed:meshHeading |
pubmed-meshheading:16597102-Artemisinins,
pubmed-meshheading:16597102-Catalysis,
pubmed-meshheading:16597102-Cell Line, Tumor,
pubmed-meshheading:16597102-Drug Screening Assays, Antitumor,
pubmed-meshheading:16597102-Gold,
pubmed-meshheading:16597102-Humans,
pubmed-meshheading:16597102-Inhibitory Concentration 50,
pubmed-meshheading:16597102-Lactones,
pubmed-meshheading:16597102-Molecular Structure,
pubmed-meshheading:16597102-Pargyline,
pubmed-meshheading:16597102-Propylamines,
pubmed-meshheading:16597102-Sesquiterpenes,
pubmed-meshheading:16597102-Stereoisomerism
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pubmed:year |
2006
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pubmed:articleTitle |
Gold(III) Salen complex-catalyzed synthesis of propargylamines via a three-component coupling reaction.
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pubmed:affiliation |
Department of Chemistry and Open Laboratory of Chemical Biology of the Institute of Molecular Technology for Drug Discovery and Synthesis, The University of Hong Kong, Pokfulam Road, Hong Kong, China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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