Source:http://linkedlifedata.com/resource/pubmed/id/16596275
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
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| pubmed:dateCreated |
2006-4-5
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| pubmed:abstractText |
Both inflammatory and anti-inflammatory cytokines have been reported to be associated with acute graft-versus-host disease (aGVHD). However, their role and possible mutual interactions during aGVHD are not well understood. Eight patients with aGVHD and eight without who had undergone allogeneic HLA-identical peripheral blood stem cell transplantation were studied. The patients had no other complications known to affect serum concentration of cytokines, including infection. Serum concentrations of IL-1beta, IL-2, IL-4, IL-5, IL-6, IL-8, IL-10, IL-12p70, TNF-alpha and IFN-gamma were concurrently measured by a new technique, the cytometric bead array (CBA). We found that serum concentrations of IL-5, IL-6 and IL-10 were significantly higher in patients with aGVHD than in patients without it. By ratiometric analysis, the ratios of IL-5/IL-2, IL-5/IL-4, IL-6/IL-4 in patients with aGVHD were increased compared to the patients with no evidence of aGVHD. ROC analysis demonstrated that the ratio of IL-5/IL-4 was the most sensitive parameter associated with aGVHD. The second best marker of aGVHD was increased IL-5 concentration. Thus, our results indicate that the ratio of a particular cytokine/cytokine could be a potential diagnostic marker for aGVHD, more sensitive that the serum level of a given cytokine. This observation is consistent with a cross-talk among some cytokines and their possible interactions via respective receptors on cytokine-producing cells; these interactions may play an important role in pathogenesis of aGVHD. Further studies including a large number of patients and concurrent measurement of a variety of cytokines are needed to fully assess the diagnostic value of the cytokine ratiometric analysis. The CBA methodology provides a convenient and useful tool in such studies.
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| pubmed:grant | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cytokines,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-10,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-2,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-4,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-5,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-6
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| pubmed:status |
MEDLINE
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| pubmed:month |
May
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| pubmed:issn |
1107-3756
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| pubmed:author |
pubmed-author:AoeKeisukeK,
pubmed-author:DarzynkiewiczZbigniewZ,
pubmed-author:FujiiNobuharuN,
pubmed-author:HirakiAkioA,
pubmed-author:IkedaKazumaK,
pubmed-author:IshimaruFumihikoF,
pubmed-author:MasudaKozoK,
pubmed-author:MatsuoKeitaroK,
pubmed-author:MurakamiTomoyukiT,
pubmed-author:ShinagawaKatsujiK,
pubmed-author:SugiKazuroK,
pubmed-author:TanimotoMitsuneM
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| pubmed:issnType |
Print
|
| pubmed:volume |
17
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
881-5
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| pubmed:dateRevised |
2010-12-3
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| pubmed:meshHeading |
pubmed-meshheading:16596275-Acute Disease,
pubmed-meshheading:16596275-Adolescent,
pubmed-meshheading:16596275-Adult,
pubmed-meshheading:16596275-Aged,
pubmed-meshheading:16596275-Cytokines,
pubmed-meshheading:16596275-Female,
pubmed-meshheading:16596275-Flow Cytometry,
pubmed-meshheading:16596275-Graft vs Host Disease,
pubmed-meshheading:16596275-Humans,
pubmed-meshheading:16596275-Interleukin-10,
pubmed-meshheading:16596275-Interleukin-2,
pubmed-meshheading:16596275-Interleukin-4,
pubmed-meshheading:16596275-Interleukin-5,
pubmed-meshheading:16596275-Interleukin-6,
pubmed-meshheading:16596275-Male,
pubmed-meshheading:16596275-Microspheres,
pubmed-meshheading:16596275-Middle Aged,
pubmed-meshheading:16596275-Peripheral Blood Stem Cell Transplantation,
pubmed-meshheading:16596275-ROC Curve,
pubmed-meshheading:16596275-Transplantation, Homologous
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| pubmed:year |
2006
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| pubmed:articleTitle |
Serum cytokine concentrations and acute graft-versus-host disease after allogeneic peripheral blood stem cell transplantation: concurrent measurement of ten cytokines and their respective ratios using cytometric bead array.
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| pubmed:affiliation |
Department of Hematology, Oncology and Respiratory Medicine, Okayama University Medical School, Okayama, Japan.
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| pubmed:publicationType |
Journal Article
|