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rdf:type |
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lifeskim:mentions |
umls-concept:C0007634,
umls-concept:C0023810,
umls-concept:C0079904,
umls-concept:C0086282,
umls-concept:C0086418,
umls-concept:C0700114,
umls-concept:C0871261,
umls-concept:C1167622,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C2911692
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pubmed:issue |
15
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pubmed:dateCreated |
2006-4-12
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pubmed:abstractText |
The NF-kappaB family of transcription factors plays a critical role in numerous cellular processes, particularly the immune response. Our understanding of how the different NF-kappaB subunits act coordinately to regulate gene expression is based on a limited set of genes. We used genome-scale location analysis to identify targets of all five NF-kappaB proteins before and after stimulation of monocytic cells with bacterial lipopolysaccharide (LPS). In unstimulated cells, p50 and p52 bound to a large number of gene promoters that were also occupied by RNA polymerase II. After LPS stimulation, additional NF-kappaB subunits bound to these genes and to other genes. Genes that became bound by multiple NF-kappaB subunits were the most likely to show increases in RNA polymerase II occupancy and gene expression. This study identifies NF-kappaB target genes, reveals how the different NF-kappaB proteins coordinate their activity, and provides an initial map of the transcriptional regulatory network that underlies the host response to infection.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/16595631-10362352,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16595631-10602464,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16595631-11090630,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16595631-11106736,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16595631-11125145,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16595631-11206552,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16595631-11562344,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16595631-11799066,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16595631-11799067,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16595631-11805289,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16595631-11931769,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16595631-12208876,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16595631-12424381,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16595631-12817009,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16595631-12820969,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16595631-1431113,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16595631-14527995,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16595631-14532125,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16595631-14743216,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16595631-14988562,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16595631-15075390,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16595631-15093710,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16595631-15145317,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16595631-15229469,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16595631-15315758,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16595631-15369667,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16595631-15371334,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16595631-15380510,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16595631-15806094,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16595631-1604322,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16595631-16175180,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16595631-1634604,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16595631-1740105,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16595631-7507207,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16595631-7834752,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16595631-7867065,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16595631-7949142,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16595631-8196637,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16595631-8614832,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16595631-8670842,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16595631-9529315
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
11
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pubmed:volume |
103
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5899-904
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:16595631-Genome, Human,
pubmed-meshheading:16595631-Humans,
pubmed-meshheading:16595631-Lipopolysaccharides,
pubmed-meshheading:16595631-NF-kappa B,
pubmed-meshheading:16595631-Protein Binding,
pubmed-meshheading:16595631-Protein Subunits,
pubmed-meshheading:16595631-RNA Polymerase II,
pubmed-meshheading:16595631-Transcription, Genetic,
pubmed-meshheading:16595631-U937 Cells
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pubmed:year |
2006
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pubmed:articleTitle |
Coordinated binding of NF-kappaB family members in the response of human cells to lipopolysaccharide.
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pubmed:affiliation |
Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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