Linked Life Data

1659547

Source:http://linkedlifedata.com/resource/pubmed/id/1659547

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1992-1-2
pubmed:abstractText
Preparations of longitudinal muscle attached to myenteric plexus from guinea pig ileum were used to observe the effect of trimebutine on intestinal motility. Electrical stimulation at 0.2 Hz and 5 Hz produced contraction mediated by the release of acetylcholine in the preparations. The response to low-frequency stimulation (0.2 Hz) was inhibited by trimebutine (10(-8)-10(-5) mol/L), and the response to high-frequency stimulation (5 Hz) was enhanced by the drug at low concentrations (10(-8)-10(-7) mol/L) and inhibited by high concentrations (10(-6)-10(-5) mol/L). This enhancement was mimicked by [D-Ala2,N-Me-Phe4,Gly5-ol]enkephalin, and was antagonized by naloxone but not by MR2266. Enhancement by trimebutine was inhibited by yohimbine. Trimebutine (greater than or equal to 10(-8) mol/L) inhibited stimulation (5 Hz)-evoked release of norepinephrine, and the trimebutine effect was antagonized by naloxone but not by MR2266. Low concentrations of trimebutine inhibit norepinephrine release via the mu-opioid receptor and enhance intestinal motility by preventing the adrenergic inhibition of acetylcholine release. Inhibition by trimebutine was antagonized either by naloxone or MR2266. High concentrations of trimebutine may inhibit acetylcholine release via the mu- and kappa-opioid receptors, after which the intestinal motility is inhibited. Trimebutine at further high concentrations (greater than 10(-5) mol/L) contracted single smooth muscle cells from the circular muscle layers but not from the longitudinal muscle layers. The usual dose of trimebutine may exert dual effect on the intestinal motility indirectly through cholinergic and adrenergic neurons without direct effect on the smooth muscle.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0016-5085
pubmed:author
pubmed:issnType
Print
pubmed:volume
101
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1579-87
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:1659547-Acetylcholine, pubmed-meshheading:1659547-Animals, pubmed-meshheading:1659547-Electric Stimulation, pubmed-meshheading:1659547-Enkephalin, Ala(2)-MePhe(4)-Gly(5)-, pubmed-meshheading:1659547-Enkephalin, D-Penicillamine (2,5)-, pubmed-meshheading:1659547-Enkephalins, pubmed-meshheading:1659547-Female, pubmed-meshheading:1659547-Gastrointestinal Motility, pubmed-meshheading:1659547-Guinea Pigs, pubmed-meshheading:1659547-Ileum, pubmed-meshheading:1659547-Male, pubmed-meshheading:1659547-Muscle, Smooth, pubmed-meshheading:1659547-Muscle Contraction, pubmed-meshheading:1659547-Naloxone, pubmed-meshheading:1659547-Norepinephrine, pubmed-meshheading:1659547-Receptors, Opioid, pubmed-meshheading:1659547-Receptors, Opioid, delta, pubmed-meshheading:1659547-Receptors, Opioid, kappa, pubmed-meshheading:1659547-Trimebutine
pubmed:year
1991
pubmed:articleTitle
Dual effect of trimebutine on contractility of the guinea pig ileum via the opioid receptors.
pubmed:affiliation
Department of Pharmacology, Kobe University School of Medicine, Japan.
pubmed:publicationType
Journal Article, In Vitro, Research Support, Non-U.S. Gov't