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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1991-12-2
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pubmed:abstractText |
Several styryl-based compounds were evaluated for their capacity to act as inhibitors of the non-receptor tyrosine protein kinase p56lck. Our results demonstrate that alpha-cyanocinnamamide compounds can inhibit both the in vitro tyrosine autophosphorylation of p56lck as well as p56lck phosphorylation of exogenous substrates. Compound 67B-83-A was found to inhibit p56lck protein kinase activity with a calculated IC50 of 7 to 10 microM. This compound did not significantly inhibit the tyrosine protein kinase activity of the epidermal growth factor receptor and was found to be a less effective tyrosine protein kinase inhibitor for other members of the src family of protein kinases.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0006-291X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
31
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pubmed:volume |
180
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1048-56
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:1659394-Animals,
pubmed-meshheading:1659394-Cell Line,
pubmed-meshheading:1659394-Kinetics,
pubmed-meshheading:1659394-Leukemia, B-Cell,
pubmed-meshheading:1659394-Leukemia-Lymphoma, Adult T-Cell,
pubmed-meshheading:1659394-Lymphocyte Specific Protein Tyrosine Kinase p56(lck),
pubmed-meshheading:1659394-Lymphocytes,
pubmed-meshheading:1659394-Mice,
pubmed-meshheading:1659394-Protein-Tyrosine Kinases,
pubmed-meshheading:1659394-Rats,
pubmed-meshheading:1659394-Receptor, Epidermal Growth Factor,
pubmed-meshheading:1659394-Structure-Activity Relationship,
pubmed-meshheading:1659394-Styrenes
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pubmed:year |
1991
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pubmed:articleTitle |
Analysis of styryl-based inhibitors of the lymphocyte tyrosine protein kinase p56lck.
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pubmed:affiliation |
Department of Molecular Biology, Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, New Jersey 08543.
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pubmed:publicationType |
Journal Article
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