Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1991-12-19
|
| pubmed:abstractText |
The relationship between chromosome breakpoints associated with T-cell antigen receptor (TCR) genes and TCR-alpha/beta/tau/delta rearrangements of peripheral leukaemic cells in 8 Japanese patients with the acute type of adult T-cell leukaemia (ATL) was examined. Break of the 14q11 region with the assigned locus of TCR-alpha/delta was revealed in 6 patients, interstitial deletion of the 7q32-36 region with assigned locus of TCR-beta in 1 patient, and break of the 7p15 region with assigned locus of TCR-tau in 2 patients. Molecular analysis revealed TCR-alpha rearrangement in 7 patients, TCR-beta rearrangement in all patients, and TCR-tau rearrangement in 5 patients. TCR-delta was deleted in all patients. These findings indicate a close relationship between 14q11 anomaly and TCR-alpha rearrangement, which may play an important role in the leukaemogenesis of ATL.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0001-5792
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
86
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
14-9
|
| pubmed:dateRevised |
2007-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:1659101-Aged,
pubmed-meshheading:1659101-Chromosome Aberrations,
pubmed-meshheading:1659101-Chromosome Deletion,
pubmed-meshheading:1659101-Chromosomes, Human, Pair 14,
pubmed-meshheading:1659101-Female,
pubmed-meshheading:1659101-Gene Rearrangement, T-Lymphocyte,
pubmed-meshheading:1659101-Gene Rearrangement, alpha-Chain T-Cell Antigen Receptor,
pubmed-meshheading:1659101-Gene Rearrangement, beta-Chain T-Cell Antigen Receptor,
pubmed-meshheading:1659101-Gene Rearrangement, delta-Chain T-Cell Antigen Receptor,
pubmed-meshheading:1659101-Humans,
pubmed-meshheading:1659101-Japan,
pubmed-meshheading:1659101-Karyotyping,
pubmed-meshheading:1659101-Leukemia-Lymphoma, Adult T-Cell,
pubmed-meshheading:1659101-Male,
pubmed-meshheading:1659101-Middle Aged,
pubmed-meshheading:1659101-Restriction Mapping
|
| pubmed:year |
1991
|
| pubmed:articleTitle |
Relationship between chromosomal breakpoint and molecular rearrangement of T-cell antigen receptors in adult T-cell leukaemia.
|
| pubmed:affiliation |
Department of Haematology, Nagasaki University School of Medicine, Japan.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|