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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1991-11-27
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pubmed:abstractText |
Kappa-carrageenan (kappa-carrageenin; kappa-carragheen) was found to be thrombogenic in rats. After i.p. injection of 3 mg/kg of kappa-carrageenan the thrombosis extended to a maximum 7.5 cm from the tip of the tail. Infarction frequency as well as the extent of infarction were inhibited by oral administration of a new heparan sulphate of low molecular weight (LMW-HS) (alpha-idosane). Mesoglycan and heparin were active when administered by parenteral route, and aspirin showed no effect; mesoglycan was inactive at 50 mg/kg per os. The present data confirm the validity of this experimental model for evaluating the protective effects of antithrombotic drugs and show the activity of oral administration of a new drug endowed with fibrinolytic activity.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1043-6618
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
24
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
59-63
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pubmed:dateRevised |
2003-11-14
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pubmed:meshHeading |
pubmed-meshheading:1658763-Animals,
pubmed-meshheading:1658763-Aspirin,
pubmed-meshheading:1658763-Carrageenan,
pubmed-meshheading:1658763-Fibrinolytic Agents,
pubmed-meshheading:1658763-Glycosaminoglycans,
pubmed-meshheading:1658763-Heparin, Low-Molecular-Weight,
pubmed-meshheading:1658763-Infarction,
pubmed-meshheading:1658763-Male,
pubmed-meshheading:1658763-Rats,
pubmed-meshheading:1658763-Rats, Inbred Strains,
pubmed-meshheading:1658763-Regional Blood Flow,
pubmed-meshheading:1658763-Tail,
pubmed-meshheading:1658763-Thrombosis
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pubmed:year |
1991
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pubmed:articleTitle |
A new low molecular weight heparan sulphate antagonizes kappa-carrageenan-induced thrombosis in rats.
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pubmed:affiliation |
Laboratori-Baldacci S.p.A., Pisa, Italy.
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pubmed:publicationType |
Journal Article
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