Source:http://linkedlifedata.com/resource/pubmed/id/16584922
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
2006-5-8
|
| pubmed:abstractText |
Memory T-cell responses generated in chronic viral infections can show functional defects contributing to poor viral control. Recently, signaling through the PD-1 receptor on CD8+ T cells was shown to cause cells to express an exhausted phenotype in an animal model of chronic infection. By blocking the interaction of PD-1 with its ligand PD-L1, virus-specific CD8+ T cells exhibited expansion and improved infection control. This approach could prove valuable to manage chronic infections.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
May
|
| pubmed:issn |
1471-4906
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
27
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
205-7
|
| pubmed:meshHeading |
pubmed-meshheading:16584922-Animals,
pubmed-meshheading:16584922-Antigens, Surface,
pubmed-meshheading:16584922-Apoptosis Regulatory Proteins,
pubmed-meshheading:16584922-Chronic Disease,
pubmed-meshheading:16584922-Humans,
pubmed-meshheading:16584922-Infection,
pubmed-meshheading:16584922-T-Lymphocytes,
pubmed-meshheading:16584922-Time Factors
|
| pubmed:year |
2006
|
| pubmed:articleTitle |
Waking up T cells to counteract chronic infections.
|
| pubmed:affiliation |
Department of Microbiology, University of Tennessee, Knoxville, TN 37996-0845, USA.
|
| pubmed:publicationType |
Journal Article
|