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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
1975-9-3
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pubmed:abstractText |
Injections of ACTH of prolonged action (twice 1.5 units per mouse) given to lethally (800 R) irradiated mice with a hind limb shielded to the middle of the tibia brought about a twofold decrease in the number of spleen colonies. ACTH injections after sublethal whole-body irradiation (600 R) did not affect the number of endogenous spleen colonies. ACTH injection of normal mice brought about a substantial decrease in the CFU content in the circulating blood at the time of increased 11-hydroxycorticosteroid concentrations in the plasma. The results obtained are interpreted as inhibition of CFU migration from a shielded area of bone marrow induced by a high 11-hydroxycorticosteroid content in the plasma that followed ACTH injections which had no mitostatic effect on CFU proliferation.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0006-4971
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
46
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
79-84
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:165842-11-Hydroxycorticosteroids,
pubmed-meshheading:165842-Adrenocorticotropic Hormone,
pubmed-meshheading:165842-Animals,
pubmed-meshheading:165842-Cell Division,
pubmed-meshheading:165842-Cell Movement,
pubmed-meshheading:165842-Fluorometry,
pubmed-meshheading:165842-Hematopoietic Stem Cells,
pubmed-meshheading:165842-Hindlimb,
pubmed-meshheading:165842-Mice,
pubmed-meshheading:165842-Radiation,
pubmed-meshheading:165842-Radiation Protection,
pubmed-meshheading:165842-Spleen,
pubmed-meshheading:165842-Tibia
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pubmed:year |
1975
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pubmed:articleTitle |
The factors controlling stem cell recirculation. II. ACTH-induced inhibition of migration of hemopoietic stem cells.
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pubmed:publicationType |
Journal Article
|